Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task.
Cognitive aging
Functional connectivity
UFOV
Useful field of view
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
03
06
2022
accepted:
20
07
2022
pubmed:
11
8
2022
medline:
2
2
2023
entrez:
10
8
2022
Statut:
ppublish
Résumé
Declines in processing speed performance occur in aging and are a critical marker of functional independence in older adults. Numerous studies suggest that Useful Field of View (UFOV) training may ameliorate cognitive decline in older adults. Despite its efficacy, little is known about the neural correlates of this task. The current study is the first to investigate the coherence of functional connectivity during UFOV task completion. A total of 336 participants completed the UFOV task while undergoing task-based functional magnetic resonance imaging (fMRI). Ten spherical regions of interest (ROIs), selected a priori, were created based on regions with the greatest peak BOLD activation patterns in the UFOV fMRI task and regions that have been shown to significantly relate to UFOV fMRI task performance. We used a weighted ROI-to-ROI connectivity analysis to model task-specific functional connectivity strength between these a priori selected ROIs. We found that our UFOV fMRI network was functionally connected during task performance and was significantly associated to UFOV fMRI task performance. Within-network connectivity of the UFOV fMRI network showed comparable or better predictive power in accounting for UFOV accuracy compared to 7 resting state networks, delineated by Yeo and colleagues. Finally, we demonstrate that the within-network connectivity of UFOV fMRI task accounted for scores on a measure of "near transfer", the Double Decision task, better than the aforementioned resting state networks. Our data elucidate functional connectivity patterns of the UFOV fMRI task. This may assist in future targeted interventions that aim to improve synchronicity within the UFOV fMRI network.
Identifiants
pubmed: 35948860
doi: 10.1007/s11357-022-00632-1
pii: 10.1007/s11357-022-00632-1
pmc: PMC9886714
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
293-309Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL134621
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG020499
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054077
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG050707
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to American Aging Association.
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