Lactotroph PitNET/adenoma associated to granulomatous hypophysitis in a patient with Crohn's disease: A case report.
Crohn's disease
granulomatous disorders
hypophysitis
lactotroph PitNET/adenoma
pituitary neuroendocrine tumours
Journal
Neuropathology : official journal of the Japanese Society of Neuropathology
ISSN: 1440-1789
Titre abrégé: Neuropathology
Pays: Australia
ID NLM: 9606526
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
revised:
21
07
2022
received:
09
05
2022
accepted:
22
07
2022
pubmed:
12
8
2022
medline:
4
2
2023
entrez:
11
8
2022
Statut:
ppublish
Résumé
Granulomatous hypophysitis is a rare and poorly understood condition. Although certain cases are treated as primary pituitary autoimmune disorders, rare cases may be associated with pituitary neuroendocrine tumours (PitNETs) and systemic inflammatory diseases. Here, we report a case of a 47-year-old man that underwent endoscopic trans-sphenoidal excision of a pituitary mass diagnosed as PitNET. On histologic evaluation, the neoplasm showed an admixture of granulomas with extensive inflammatory infiltrate and lactotroph PitNET/adenoma. Careful anamnestic examination revealed a diagnosis of Crohn's disease 20 years prior. Although rarely done, both PitNET and Crohn's disease may be associated with granulomatous hypophysitis, and our patient had both conditions. During the 6-year follow-up, PitNETs and hypophysitis did not recur, while Crohn's disease was only partially controlled by medical therapy. To our knowledge, this is the first description of association of granulomatous hypophysitis, PitNET and Crohn's disease.
Identifiants
pubmed: 35949102
doi: 10.1111/neup.12857
pmc: PMC10087785
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-109Informations de copyright
© 2022 The Authors. Neuropathology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Neuropathology.
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