Immunomodulation in age-related disorders and nanotechnology interventions.
age-related diseases
aging
immunomodulation
nanoparticles
nanotechnology
Journal
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
ISSN: 1939-0041
Titre abrégé: Wiley Interdiscip Rev Nanomed Nanobiotechnol
Pays: United States
ID NLM: 101508311
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
19
05
2022
received:
24
12
2021
accepted:
01
06
2022
pmc-release:
01
01
2024
pubmed:
12
8
2022
medline:
17
1
2023
entrez:
11
8
2022
Statut:
ppublish
Résumé
Recently, the aging population has increased exponentially around the globe bringing more challenges to improve quality of life in those populations while reducing the economic burden on healthcare systems. Aging is associated with changes in the immune system culminating in detrimental effects such as immune dysfunction, immunosenescence, and chronic inflammation. Age-related decline of immune functions is associated with various pathologies including cardiovascular, autoimmune, neurodegenerative, and infectious diseases to name a few. Conventional treatment addresses the onset of age-related diseases by early detection of risk factors, administration of vaccines as preventive care, immunomodulatory treatment, and other dietary supplements. However, these approaches often come with systemic side-effects, low bioavailability of therapeutic agents, and poor outcomes seen in the elderly. Recent innovations in nanotechnology have led to the development of novel biomaterials/nanomaterials, which explore targeted drug delivery and immunomodulatory interactions in vivo. Current nanotechnology-based immunomodulatory approaches that have the potential to be used as therapeutic interventions for some prominent age-related diseases are discussed here. Finally, we explore challenges and future aspects of nanotechnology in the treatments of age-related disorders to improve quality of life in the elderly. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
Identifiants
pubmed: 35950266
doi: 10.1002/wnan.1840
pmc: PMC9840662
mid: NIHMS1826146
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1840Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL158204
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL156076
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134613
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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