Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain.
Epigenetics
aging
brain aging
chronic pain
musculoskeletal pain
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
pubmed:
12
8
2022
medline:
15
11
2022
entrez:
11
8
2022
Statut:
ppublish
Résumé
Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of aging are associated with each other in those with chronic pain. We aimed to explore the association of epigenetic aging and brain aging in middle-to-older age individuals with varying degrees of knee pain. Participants (57.91 ± 8.04 y) with low impact knee pain (n = 95), high impact knee pain (n = 53), and pain-free controls (n = 26) completed self-reported pain, a blood draw, and an MRI scan. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), the subsequent difference of predicted epigenetic and brain age from chronological age (DNAmGrimAge-Difference and Brain-PAD, respectively). There was a significant main effect for pain impact group (
Identifiants
pubmed: 35950599
doi: 10.1080/15592294.2022.2111752
pmc: PMC9665126
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2178-2187Subventions
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG033906
Pays : United States
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