Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain.
Carbon-11 Radiotracer
Ionic Channel
PET Imaging
TRPC 5
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
20
04
2022
accepted:
14
07
2022
revised:
12
07
2022
pmc-release:
01
04
2024
pubmed:
12
8
2022
medline:
15
3
2023
entrez:
11
8
2022
Statut:
ppublish
Résumé
TRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca [ [ Our data showed that [
Identifiants
pubmed: 35951211
doi: 10.1007/s11307-022-01760-y
pii: 10.1007/s11307-022-01760-y
pmc: PMC9918595
mid: NIHMS1833074
doi:
Substances chimiques
Carbon Radioisotopes
0
Carbon-11
0
Radiopharmaceuticals
0
TRPC Cation Channels
0
Trpc5 protein, rat
0
Trpc5 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
334-342Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103988
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107281
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075321
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075527
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to World Molecular Imaging Society.
Références
Clapham DE, Runnels LW, Strübing C (2001) The TRP ion channel family. Nat Rev Neurosci 2:387–396
doi: 10.1038/35077544
pubmed: 11389472
Riccio A, Li Y, Moon J et al (2009) Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137:761–772
doi: 10.1016/j.cell.2009.03.039
pubmed: 19450521
pmcid: 2719954
Sharma S, Hopkins CR (2019) Review of transient receptor potential canonical (TRPC5) Channel modulators and diseases. J Med Chem 62:7589–7602
doi: 10.1021/acs.jmedchem.8b01954
pubmed: 30943030
Wang H, Cheng X, Tian J et al (2020) TRPC channels: structure, function, regulation and recent advances in small molecular probes. Pharmacol Ther 209:107497
doi: 10.1016/j.pharmthera.2020.107497
pubmed: 32004513
pmcid: 7183440
Wright DJ, Simmons KJ, Johnson RM, Beech DJ, Muench SP, Bon RS (2020) Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. Commun Biol 3:704
doi: 10.1038/s42003-020-01437-8
pubmed: 33230284
pmcid: 7683545
GFB-887 for TRPC5-Rac1-Mediated FSGS. Goldfinch Bio Company website (2022) https://www.goldfinchbio.com/pipeline/gfb-887/ . Accessed 28 July 2022
Yu Y, Liang Q, Liu H et al (2019) Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain. Org Biomol Chem 17:5586–5594
doi: 10.1039/C9OB00893D
pubmed: 31115430
pmcid: 6582641
Yu Y, Liang Q, Du L et al (2020) Synthesis and characterization of a specific iodine-125-labeled TRPC5 radioligand. ChemMedChem 15:1854–1860
doi: 10.1002/cmdc.202000339
pubmed: 32717096
pmcid: 8544919
Chenard B, Gallaschun R (2014) Substituted xanthines and methods of use thereof. Global patent, WO2014143799 A2
Just S, Chenard BL, Ceci A et al (2018) Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One 13:e0191225
doi: 10.1371/journal.pone.0191225
pubmed: 29385160
pmcid: 5791972
Song K, Wei M, Guo W et al (2021) Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife 10:e63429
doi: 10.7554/eLife.63429
pubmed: 33683200
pmcid: 7987348
Waterhouse RN (2003) Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents. Mol Imaging Biol 5:376–389
doi: 10.1016/j.mibio.2003.09.014
pubmed: 14667492
Pike VW (2016) Considerations in the development of reversibly binding PET Radioligands for brain imaging. Curr Med Chem 23:1818–1869
doi: 10.2174/0929867323666160418114826
pubmed: 27087244
pmcid: 5579844
Wilson AA, Jin L, Garcia A, DaSilva JN, Houle S (2001) An admonition when measuring the lipophilicity of radiotracers using counting techniques. Appl Radiat Isot 54:203–208
doi: 10.1016/S0969-8043(00)00269-4
pubmed: 11200881
Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645–655
doi: 10.1016/S0896-6273(01)00240-9
pubmed: 11301024
Chung YH, Sun Ahn H, Kim D et al (2006) Immunohistochemical study on the distribution of TRPC channels in the rat hippocampus. Brain Res 1085:132–137
doi: 10.1016/j.brainres.2006.02.087
pubmed: 16580647
Riccio A, Medhurst AD, Mattei C et al (2002) mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 109:95–104
doi: 10.1016/S0169-328X(02)00527-2
pubmed: 12531519
Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC (2007) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One 2:e573
doi: 10.1371/journal.pone.0000573
pubmed: 17593972
pmcid: 1892805
Zhang L, Villalobos A, Beck EM et al (2013) Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand. J Med Chem 56:4568–4579
doi: 10.1021/jm400312y
pubmed: 23651455
Jeffries B, Wang Z, Graton J et al (2018) Reducing the lipophilicity of perfluoroalkyl groups by CF(2)-F/CF(2)-Me or CF(3)/CH(3) Exchange. J Med Chem 61:10602–10618
doi: 10.1021/acs.jmedchem.8b01222
pubmed: 30411895
Shultz MD (2013) Setting expectations in molecular optimizations: strengths and limitations of commonly used composite parameters. Bioorg Med Chem Lett 23:5980–5991
doi: 10.1016/j.bmcl.2013.08.029
pubmed: 24018190
Phelan KD, Shwe UT, Abramowitz J et al (2013) Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol 83:429–438
doi: 10.1124/mol.112.082271
pubmed: 23188715
pmcid: 3558807
Alawi KM, Russell FA, Aubdool AA et al (2017) Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. Ann Rheum Dis 76:252–260
doi: 10.1136/annrheumdis-2015-208886
pubmed: 27165180