Therapeutic effects of a soluble guanylate cyclase activator, BAY 60-2770, on lower urinary tract dysfunction in mice with spinal cord injury.


Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 10 2022
Historique:
pubmed: 12 8 2022
medline: 17 9 2022
entrez: 11 8 2022
Statut: ppublish

Résumé

We aimed to evaluate the effects of a soluble guanylate cyclase (sGC) activator, BAY 60-2770, on neurogenic lower urinary tract dysfunction in mice with spinal cord injury (SCI). Mice were divided into the following three groups: spinal cord intact (

Identifiants

pubmed: 35952343
doi: 10.1152/ajprenal.00105.2022
pmc: PMC9485004
doi:

Substances chimiques

4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid 0
Benzoates 0
Biphenyl Compounds 0
Hydrocarbons, Fluorinated 0
RNA, Messenger 0
Nitric Oxide Synthase EC 1.14.13.39
Soluble Guanylyl Cyclase EC 4.6.1.2

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

F447-F454

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK129194
Pays : United States

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Auteurs

Daisuke Gotoh (D)

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Urology, Nara Medical University, Kashihara, Japan.

Tetsuichi Saito (T)

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Sergei Karnup (S)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Yosuke Morizawa (Y)

Department of Urology, Nara Medical University, Kashihara, Japan.

Shunta Hori (S)

Department of Urology, Nara Medical University, Kashihara, Japan.

Yasushi Nakai (Y)

Department of Urology, Nara Medical University, Kashihara, Japan.

Makito Miyake (M)

Department of Urology, Nara Medical University, Kashihara, Japan.

Kazumasa Torimoto (K)

Department of Urology, Nara Medical University, Kashihara, Japan.

Kiyohide Fujimoto (K)

Department of Urology, Nara Medical University, Kashihara, Japan.

Naoki Yoshimura (N)

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Classifications MeSH