Genetic ancestry and population structure of vaccinia virus.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
11 Aug 2022
11 Aug 2022
Historique:
received:
27
05
2022
accepted:
28
07
2022
entrez:
11
8
2022
pubmed:
12
8
2022
medline:
12
8
2022
Statut:
epublish
Résumé
Vaccinia virus (VACV) was used for smallpox eradication, but its ultimate origin remains unknown. The genetic relationships among vaccine stocks are also poorly understood. We analyzed 63 vaccine strains with different origin, as well horsepox virus (HPXV). Results indicated the genetic diversity of VACV is intermediate between variola and cowpox viruses, and that mutation contributed more than recombination to VACV evolution. STRUCTURE identified 9 contributing subpopulations and showed that the lowest drift was experienced by the ancestry components of Tian Tan and HPXV/Mütter/Mulford genomes. Subpopulations that experienced very strong drift include those that contributed the ancestry of MVA and IHD-W, in good agreement with the very long passage history of these vaccines. Another highly drifted population contributed the full ancestry of viruses sampled from human/cattle infections in Brazil and, partially, to IOC clones, strongly suggesting that the recurrent infections in Brazil derive from the spillback of IOC to the feral state.
Identifiants
pubmed: 35953491
doi: 10.1038/s41541-022-00519-4
pii: 10.1038/s41541-022-00519-4
pmc: PMC9372083
doi:
Types de publication
Journal Article
Langues
eng
Pagination
92Subventions
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : Ricerca corrente 2021-2022
Informations de copyright
© 2022. The Author(s).
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