A Wholistic View of How Bumetanide Attenuates Autism Spectrum Disorders.
ASD
NKCC1
alzheimer’s disease
blood-brain barrier
brain-gut interactions
bumetanide
central and peripheral actions of bumetanide
clinical trials
immune alterations in brain disorders
neurodevelopmental disorders
parkinson’s disease
side effects
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 08 2022
04 08 2022
Historique:
received:
21
06
2022
revised:
22
07
2022
accepted:
03
08
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
The specific NKCC1 cotransporter antagonist, bumetanide, attenuates the severity of Autism Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders in animal models and clinical trials. However, the pervasive expression of NKCC1 in many cell types throughout the body is thought to challenge the therapeutic efficacy of bumetanide. However, many peripheral functions, including intestinal, metabolic, or vascular, etc., are perturbed in brain disorders contributing to the neurological sequels. Alterations of these functions also increase the incidence of the disorder suggesting complex bidirectional links with the clinical manifestations. We suggest that a more holistic view of ASD and other disorders is warranted to account for the multiple sites impacted by the original intra-uterine insult. From this perspective, large-spectrum active repositioned drugs that act centrally and peripherally might constitute a useful approach to treating these disorders.
Identifiants
pubmed: 35954263
pii: cells11152419
doi: 10.3390/cells11152419
pmc: PMC9367773
pii:
doi:
Substances chimiques
Solute Carrier Family 12, Member 2
0
Bumetanide
0Y2S3XUQ5H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093501
Pays : United States
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