Integration of p16/HPV DNA Status with a 24-miRNA-Defined Molecular Phenotype Improves Clinically Relevant Stratification of Head and Neck Cancer Patients.
HNSCC
HPV
head and neck cancer
interaction
mRNA
miRNA
prediction
prognosis
signaling pathways
signature
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
31 Jul 2022
31 Jul 2022
Historique:
received:
27
06
2022
revised:
27
07
2022
accepted:
29
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Human papillomavirus (HPV)-driven head and neck squamous cell carcinomas (HNSCC) generally have a more favourable prognosis. We hypothesized that HPV-associated HNSCC may be identified by an miRNA-signature according to their specific molecular pathogenesis, and be characterized by a unique transcriptome compared to HPV-negative HNSCC. We performed miRNA expression profiling of two p16/HPV DNA characterized HNSCC cohorts of patients treated by adjuvant radio(chemo)therapy (multicentre DKTK-ROG
Identifiants
pubmed: 35954409
pii: cancers14153745
doi: 10.3390/cancers14153745
pmc: PMC9367561
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Federal Ministry of Education and Research
ID : 02NUK047A
Organisme : Federal Ministry of Education and Research
ID : 02NUK047C
Organisme : Federal Ministry of Education and Research
ID : 02NUK047F
Références
Br J Cancer. 2012 Apr 24;106(9):1526-34
pubmed: 22472886
Clin Cancer Res. 2019 Dec 15;25(24):7281-7286
pubmed: 31527164
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Natl Cancer Inst. 2009 Nov 4;101(21):1446-52
pubmed: 19815849
Eur J Cancer. 2017 May;77:3-12
pubmed: 28347920
Clin Cancer Res. 2016 Jun 1;22(11):2639-49
pubmed: 26755529
Oral Oncol. 2015 Apr;51(4):321-31
pubmed: 25677760
Oncology (Williston Park). 2020 Apr 10;34(4):
pubmed: 32293695
Radiat Oncol. 2020 May 14;15(1):109
pubmed: 32410693
Lancet Oncol. 2014 Nov;15(12):1319-31
pubmed: 25439690
Transl Cancer Res. 2019 Oct;8(6):2439-2448
pubmed: 35116996
Int J Cancer. 2017 Aug 1;141(3):594-603
pubmed: 28480996
Cell Death Dis. 2019 Jul 15;10(8):540
pubmed: 31308358
Nature. 2015 Jan 29;517(7536):576-82
pubmed: 25631445
Mol Oncol. 2018 Dec;12(12):2085-2101
pubmed: 30259648
Clin Cancer Res. 2016 Sep 15;22(18):4643-50
pubmed: 27036135
Lancet Oncol. 2016 Apr;17(4):440-451
pubmed: 26936027
Cancer Lett. 2017 Feb 1;386:87-99
pubmed: 27867017
Radiat Oncol. 2020 Jan 6;15(1):7
pubmed: 31906998
Radiother Oncol. 2014 Dec;113(3):317-23
pubmed: 25480095
Transl Oncol. 2020 Sep;13(9):100802
pubmed: 32474365
Genome Biol. 2014;15(12):550
pubmed: 25516281
J Clin Oncol. 2013 Feb 10;31(5):543-50
pubmed: 23295795
Ann Transl Med. 2020 Sep;8(18):1120
pubmed: 33240969
Clin Cancer Res. 2018 Dec 1;24(23):6001-6014
pubmed: 30087144
J Clin Microbiol. 2005 Sep;43(9):4868-71
pubmed: 16145162
Int J Cancer. 2007 Dec 1;121(11):2465-72
pubmed: 17680565
Int J Mol Sci. 2017 Jan 27;18(2):
pubmed: 28134831
N Engl J Med. 2010 Jul 1;363(1):24-35
pubmed: 20530316
Eur J Cancer. 2005 Aug;41(12):1690-6
pubmed: 16043346
Oral Oncol. 2019 Dec;99:104460
pubmed: 31683169
Clin Cancer Res. 2022 Mar 01;28(5):1038-1052
pubmed: 34965946
J Clin Virol. 2007 Dec;40(4):321-4
pubmed: 17981499
Nat Commun. 2018 Jan 2;9(1):20
pubmed: 29295995
Clin Cancer Res. 2019 Mar 1;25(5):1505-1516
pubmed: 30171046
Radiat Oncol. 2018 Jul 3;13(1):123
pubmed: 29970111
Int J Med Sci. 2020 Jan 1;17(1):112-124
pubmed: 31929745
Radiother Oncol. 2018 Apr;127(1):27-35
pubmed: 29295747
Head Neck. 2011 Apr;33(4):504-12
pubmed: 20652977
Cell Death Dis. 2021 Dec 15;12(12):1162
pubmed: 34911941
BMC Genomics. 2015 Sep 02;16:654
pubmed: 26328888
Nat Methods. 2017 Apr;14(4):417-419
pubmed: 28263959
Eur J Cancer. 2014 Oct;50(15):2619-35
pubmed: 25103455
Int J Mol Sci. 2015 Dec 18;16(12):30204-22
pubmed: 26694379
Cancer Res. 2013 Mar 15;73(6):1733-41
pubmed: 23288508
Int J Dent. 2013;2013:650218
pubmed: 24260035