Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma.
PDAC
amino acids
glucose
immune response
lipids
metabolism
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Aug 2022
04 Aug 2022
Historique:
received:
30
06
2022
revised:
01
08
2022
accepted:
03
08
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Metabolism plays a fundamental role in both human physiology and pathology, including pancreatic ductal adenocarcinoma (PDAC) and other tumors. Anabolic and catabolic processes do not only have energetic implications but are tightly associated with other cellular activities, such as DNA duplication, redox reactions, and cell homeostasis. PDAC displays a marked metabolic phenotype and the observed reduction in tumor growth induced by calorie restriction with in vivo models supports the crucial role of metabolism in this cancer type. The aggressiveness of PDAC might, therefore, be reduced by interventions on bioenergetic circuits. In this review, we describe the main metabolic mechanisms involved in PDAC growth and the biological features that may favor its onset and progression within an immunometabolic context. We also discuss the need to bridge the gap between basic research and clinical practice in order to offer alternative therapeutic approaches for PDAC patients in the more immediate future.
Identifiants
pubmed: 35954462
pii: cancers14153799
doi: 10.3390/cancers14153799
pmc: PMC9367608
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Rosaria Bendetti
ID : V:ALERE 2020-"CIRCE"
Organisme : Lucia Altucci
ID : Campania Regional Government Technology Platform 2038 Lotta alle Patologie Oncologiche iCURE-B21C17000030007
Organisme : Lucia Altucci
ID : Campania Regional Government FASE2: IDEAL
Organisme : Lucia Altucci
ID : MIUR, Proof of Concept POC01_00043
Organisme : Lucia Altucci
ID : "NUovi fArmaci e Biomarkers di risposta e resistenza farmaCo-logica nel Cancro del colon rettO-NABUCCO 1682, MISE2020
Organisme : Ugo Chianese
ID : POR Campania FSE 2014-2020 ASSE III
Organisme : Eugenia Passaro
ID : PON RI 2014/2020 "Dottorati Innovativi con caratterizzazione industriale"
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