Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors.
CCR5
CD4 T cells
CD8 T cells
CXCR3
CXCR4
carcinoma-associated fibroblasts
chemokines
pancreatic cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
06 Aug 2022
06 Aug 2022
Historique:
received:
20
04
2022
revised:
21
07
2022
accepted:
03
08
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
The accumulation of T cells is associated with a better prognosis in pancreatic cancer. However, the immunosuppressive tumor microenvironment, largely composed by cancer-associated fibroblasts (CAFs), can prevent T cells from reaching the tumor nests. We examined how human CAFs modulated chemokine receptors known to be associated with T cell trafficking, CXCR3 and CCR5, and T cell exclusion, CXCR4. CAFs decreased the expression of CXCR3 and CCR5 but increased CXCR4 expression in both 2D and 3D cultures, affecting the migratory capacity of T cells towards CXCL10. An immunohistochemistry analysis showed that very few T cells were found in the tumor nests. Within the stroma, CD8
Identifiants
pubmed: 35954489
pii: cancers14153826
doi: 10.3390/cancers14153826
pmc: PMC9367555
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swedish Cancer Foundation
ID : 20 1162 PjF
Organisme : Cancer Society in Stockholm
ID : 201152
Organisme : Cancer and Allergy Foundation
ID : 10388
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