Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review.
Brugada syndrome
endomyocardial biopsy
forensic pathology
histopathology
sudden cardiac death
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
28 Jul 2022
28 Jul 2022
Historique:
received:
12
06
2022
revised:
26
07
2022
accepted:
27
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes.
Identifiants
pubmed: 35956023
pii: jcm11154406
doi: 10.3390/jcm11154406
pmc: PMC9368908
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : La Caixa Foundation
ID : LCF/PR/GN16/50290001
Organisme : La Caixa Foundation
ID : LCF/PR/GN19/50320002
Organisme : Fundacio Marato TV3
ID : 245/U/2020
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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