Activated Protein C Ameliorates Tubular Mitochondrial Reactive Oxygen Species and Inflammation in Diabetic Kidney Disease.
activated protein C
diabetic nephropathy
inflammasome
reactive oxygen species
renal inflammation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Jul 2022
29 Jul 2022
Historique:
received:
04
07
2022
revised:
25
07
2022
accepted:
28
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage renal disease and is associated with an excessive risk of cardiovascular morbidity and mortality. DKD is a consequence of systemic endothelial dysfunction. The endothelial-dependent cytoprotective coagulation protease activated protein C (aPC) ameliorates glomerular damage in DKD, in part by reducing mitochondrial ROS generation in glomerular cells. Whether aPC reduces mitochondrial ROS generation in the tubular compartment remains unknown. Here, we conducted expression profiling of kidneys in diabetic mice (wild-type and mice with increased plasma levels of aPC, APC
Identifiants
pubmed: 35956315
pii: nu14153138
doi: 10.3390/nu14153138
pmc: PMC9370435
pii:
doi:
Substances chimiques
Protein C
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : IS-67/8-1, IS-67/11-1, IS 67/16-1, IS 67/22-1,
Organisme : Deutsche Forschungsgemeinschaft
ID : 236360313/SFB 1118, CRC854/B26 and 361210922/GRK2408/P7&P9 to B.I.; SFB854/A01, ME-1365/7-2, ME1365/9-2 to P.R.M., RTG2408/P5, SH 849/1-2 to K.S., and KO 5736/1-1 to S.K.),
Organisme : German Academic Exchange Service
ID : Year-2016
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