Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions.
chromatin maturity
genome instability
lifestyle factors
male BMI
male age
oxidative stress
semen parameters
sperm DNA fragmentation
sperm aneuploidy
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
04
07
2022
revised:
22
07
2022
accepted:
28
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Endogenous and exogenous factors can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. The extent to which men with and without subfertility are exposed to several adverse lifestyle factors and the impact on sperm DNA fragmentation (SDF), sperm chromatin maturity (condensation and decondensation), stability (hypo- and hypercondensation) and sperm aneuploidy are assessed in this study. Standardized assays employing flow cytometry were used to detect genome instability in 556 samples. Semen parameters deteriorated with age, BMI, increased physical activity and smoking. Age and BMI were associated with increased SDF. Increased BMI was associated with increased hypocondensed chromatin and decreased decondensed chromatin. Increase in age also caused an increase in sex chromosome aneuploidy in sperms. Surprisingly, alcohol abuse reduced chromatin hypercondensation and drug abuse reduced SDF. Although genome instability was more pronounced in the subfertile population as compared to the fertile group, the proportion of men with at least one lifestyle risk factor was the same in both the fertile and subfertile groups. While one in three benefited from nutritional supplementation, one in five showed an increase in SDF after supplementation. Whilst the message of 'no smoking, no alcohol, no drugs, but a healthy diet' should be offered as good health advice, we are a long way from concluding that nutritional supplementation would be beneficial for male fertility.
Identifiants
pubmed: 35956329
pii: nu14153155
doi: 10.3390/nu14153155
pmc: PMC9370520
pii:
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research Foundation - Flanders
ID : T007016N
Références
J Assist Reprod Genet. 2013 Nov;30(11):1513-8
pubmed: 24046023
Hum Reprod. 2000 Nov;15(11):2360-8
pubmed: 11056133
Fertil Steril. 2015 Jan;103(1):66-71
pubmed: 25497466
Reprod Biol Endocrinol. 2015 Apr 19;13:35
pubmed: 25928123
N Engl J Med. 2001 Nov 8;345(19):1388-93
pubmed: 11794171
Hum Reprod. 2005 Sep;20(9):2590-4
pubmed: 15932912
Hum Reprod. 2004 Oct;19(10):2298-302
pubmed: 15319393
Drugs Today (Barc). 2007 Oct;43(10):717-24
pubmed: 17987224
J Addict Med. 2013 Jan-Feb;7(1):58-65
pubmed: 23296201
Clin Biochem. 2018 Dec;62:47-54
pubmed: 29792832
J Androl. 2006 May-Jun;27(3):414-20
pubmed: 16474017
Microcirculation. 2007 Jun-Jul;14(4-5):375-87
pubmed: 17613809
Andrologia. 2018 Apr;50(3):
pubmed: 28856695
Hum Reprod. 2001 Oct;16(10):2160-5
pubmed: 11574509
J Nutr Biochem. 2007 Jun;18(6):357-71
pubmed: 17156994
Fertil Steril. 2001 Apr;75(4):674-7
pubmed: 11287017
Mol Hum Reprod. 2010 Jan;16(1):23-9
pubmed: 19933313
Cell Tissue Res. 2005 Oct;322(1):33-41
pubmed: 15912407
Environ Health Perspect. 2002 May;110(5):479-86
pubmed: 12003751
Cytogenet Genome Res. 2004;107(1-2):83-94
pubmed: 15305060
Mol Hum Reprod. 2010 Jan;16(1):37-47
pubmed: 19906823
J Assist Reprod Genet. 2019 Jul;36(7):1413-1421
pubmed: 31089933
Fertil Steril. 2004 May;81(5):1289-95
pubmed: 15136092
Spermatogenesis. 2012 Oct 1;2(4):253-263
pubmed: 23248766
Mol Reprod Dev. 2018 Mar;85(3):271-280
pubmed: 29392876
Andrologia. 2013 Jun;45(3):211-6
pubmed: 22943406
Andrology. 2016 Nov;4(6):1084-1093
pubmed: 27410398
Curr Obes Rep. 2015 Dec;4(4):401-10
pubmed: 26374640
Hum Reprod. 2010 Apr;25(4):824-38
pubmed: 20139429
Toxicology. 2006 Jun 1;223(1-2):54-60
pubmed: 16621218
Fertil Steril. 2009 May;91(5 Suppl):2221-9
pubmed: 18440520
Andrologia. 2011 Aug;43(4):286-91
pubmed: 21486403
Hum Reprod. 2002 May;17(5):1299-305
pubmed: 11980755
Andrologia. 2021 Feb;53(1):e13706
pubmed: 32559347
Andrology. 2013 May;1(3):357-60
pubmed: 23596042
Microsc Res Tech. 2003 May 1;61(1):56-75
pubmed: 12672123
Zygote. 2010 Nov;18(4):357-65
pubmed: 20663262
Bioessays. 2000 May;22(5):423-30
pubmed: 10797482
Ageing Res Rev. 2015 Jan;19:22-33
pubmed: 25462195
Placenta. 2003 Oct;24 Suppl B:S62-5
pubmed: 14559032
Hum Reprod. 1996 Apr;11(4):837-43
pubmed: 8671337
Andrologia. 2011 Apr;43(2):121-8
pubmed: 21382066
J Androl. 2012 Jan-Feb;33(1):53-8
pubmed: 21273503
Hum Reprod. 2014 Jul;29(7):1567-74
pubmed: 24838701
Reprod Biomed Online. 2009 Jun;18(6):761-8
pubmed: 19490779
Fertil Steril. 2013 Apr;99(5):1324-1331.e1
pubmed: 23290741
Fertil Steril. 2011 Apr;95(5):1700-4
pubmed: 21145051
Reprod Biomed Online. 2014 Jun;28(6):684-703
pubmed: 24745838
Cytogenet Cell Genet. 2000;90(3-4):219-26
pubmed: 11124518
Hum Reprod. 2000 Feb;15(2):351-65
pubmed: 10655307
Clin Med Insights Reprod Health. 2015 Nov 11;9:21-7
pubmed: 26604851
Reprod Biomed Online. 2008 Apr;16(4):492-503
pubmed: 18413057
Fertil Steril. 2008 Dec;90(6):2222-5
pubmed: 18178190
Fertil Steril. 2008 Nov;90(5 Suppl):S178-80
pubmed: 19007622
Genet Test Mol Biomarkers. 2012 Sep;16(9):1001-6
pubmed: 22731648
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9601-6
pubmed: 16766665
Reprod Biol. 2019 Dec;19(4):316-321
pubmed: 31744770
Syst Biol Reprod Med. 2012 Oct;58(5):255-62
pubmed: 22578234
Cochrane Database Syst Rev. 2022 May 4;5:CD007411
pubmed: 35506389
Fertil Steril. 2013 May;99(6):1654-62
pubmed: 23394781
CMAJ. 2006 Aug 29;175(5):495-500
pubmed: 16940270
J Androl. 2006 Jan-Feb;27(1):53-9
pubmed: 16400078
Cell. 1992 May 29;69(5):759-67
pubmed: 1591776
Med Princ Pract. 2008;17(2):108-16
pubmed: 18287793
Fertil Steril. 2002 Sep;78(3):491-9
pubmed: 12215323
Syst Biol Reprod Med. 2016 Dec;62(6):387-395
pubmed: 27792396
Hum Reprod. 2016 Feb;31(2):227-32
pubmed: 26682580
Reprod Biol Endocrinol. 2014 Jul 29;12:71
pubmed: 25073983
Int J Androl. 2009 Feb;32(1):46-56
pubmed: 19076252
Andrologia. 2007 Dec;39(6):203-15
pubmed: 18076419
Int J Fertil Steril. 2016 Apr-Jun;10(1):120-6
pubmed: 27123209
J Androl. 2005 May-Jun;26(3):349-53
pubmed: 15867002
Mol Hum Reprod. 2010 Jan;16(1):30-6
pubmed: 19748904
J Androl. 2003 May-Jun;24(3):438-47
pubmed: 12721220
Reproduction. 2005 Apr;129(4):505-14
pubmed: 15798026
Hum Reprod. 2020 Oct 1;35(10):2188-2196
pubmed: 32976601
Int J Epidemiol. 1995 Apr;24(2):381-8
pubmed: 7635600
Am J Epidemiol. 2017 Oct 15;186(8):910-917
pubmed: 28498890
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11003-6
pubmed: 1763015
Fertil Steril. 2003 Dec;80(6):1431-6
pubmed: 14667879
Adv Exp Med Biol. 2014;791:173-89
pubmed: 23955679
Hum Reprod Update. 2017 Nov 1;23(6):646-659
pubmed: 28981654
J Psychoactive Drugs. 2001 Jul-Sep;33(3):223-32
pubmed: 11718315
Fertil Steril. 2014 Jan;101(1):58-63.e3
pubmed: 24140035
Mol Aspects Med. 2004 Feb-Apr;25(1-2):191-8
pubmed: 15051327
Mol Med. 2015 Jan 30;21:109-22
pubmed: 25786204
Hum Reprod. 1995 May;10(5):1280-6
pubmed: 7657780
Fertil Steril. 2011 Jan;95(1):116-23
pubmed: 20674912
Aust N Z J Obstet Gynaecol. 2007 Jun;47(3):216-21
pubmed: 17550489
Arch Androl. 2003 Mar-Apr;49(2):83-94
pubmed: 12623744
Arch Androl. 2003 Jan-Feb;49(1):49-55
pubmed: 12647778
Urology. 2008 Mar;71(3):490-4
pubmed: 18342194
Fertil Steril. 2010 May 1;93(7):2222-31
pubmed: 19261274
Fertil Steril. 2008 May;89(5):1183-1190
pubmed: 17669405
Clin Endocrinol (Oxf). 2020 Sep;93(3):312-321
pubmed: 32362009
Int J Mol Sci. 2012 Oct 31;13(11):14026-52
pubmed: 23203048
J Androl. 2002 Jan-Feb;23(1):25-43
pubmed: 11780920
Scand J Urol Nephrol. 1988;22(1):1-6
pubmed: 3387905
Fertil Steril. 2009 Jan;91(1):185-92
pubmed: 18440524
BJU Int. 2012 Sep;110(6):863-7
pubmed: 22300410
Hum Reprod Update. 2005 Jul-Aug;11(4):337-49
pubmed: 15863434
Fertil Steril. 2005 Apr;83(4):923-8
pubmed: 15820802
Reprod Biomed Online. 2014 Apr;28(4):492-502
pubmed: 24581602
J Assist Reprod Genet. 2016 Dec;33(12):1633-1648
pubmed: 27423667
Hum Reprod. 2004 Jun;19(6):1245-9
pubmed: 15105399
Andrologia. 2018 Oct;50(8):e13012
pubmed: 29644708
Int J Androl. 1999 Aug;22(4):236-42
pubmed: 10442296
Andrologia. 2018 Apr;50(3):
pubmed: 29124782
Andrology. 2018 Nov;6(6):811-816
pubmed: 30298673
Am J Epidemiol. 2009 Sep 1;170(5):559-65
pubmed: 19635736
Syst Biol Reprod Med. 2011 Feb;57(1-2):78-85
pubmed: 21208147
Andrology. 2020 Jan;8(1):27-52
pubmed: 31692249
Int J Androl. 2011 Feb;34(1):2-13
pubmed: 20158539
Fertil Steril. 2007 Jan;87(1):217-9
pubmed: 17081539
Fertil Steril. 1997 Sep;68(3):519-24
pubmed: 9314926
Int J Androl. 1990 Dec;13(6):452-62
pubmed: 1710607
Hum Reprod. 2006 Nov;21(11):2876-81
pubmed: 16793992
Hum Reprod. 2004 Jun;19(6):1401-8
pubmed: 15117894
Reproduction. 2019 Jan;157(1):R15-R31
pubmed: 30390610
Asian J Androl. 2008 Mar;10(2):201-6
pubmed: 18097513
Fertil Steril. 2016 Sep 1;106(3):566-573.e10
pubmed: 27260688
J Assist Reprod Genet. 2007 Oct;24(10):437-43
pubmed: 17768675
Int J Androl. 1997 Aug;20(4):201-8
pubmed: 9401822
Hum Reprod. 1995 Jul;10(7):1736-9
pubmed: 8582971
Lancet. 1998 Oct 10;352(9135):1172-7
pubmed: 9777833
Reprod Biomed Online. 2007 Apr;14(4):418-21
pubmed: 17425820
Mol Hum Reprod. 2013 Oct;19(10):634-43
pubmed: 23720770
Int J Reprod Biomed. 2017 Jun;15(6):331-344
pubmed: 29177237
Hum Fertil (Camb). 2015 Sep;18(3):225-9
pubmed: 26090928
Fertil Steril. 2012 Jan;97(1):53-9
pubmed: 22078783