Improvements of nuclease and nickase gene modification techniques for the treatment of genetic diseases.
Adenosine Base Editor (ABE)
CRISPR-cas
Cytidine Base Editor (CBE)
TALEN
ZFN
gene editing
prime editing
Journal
Frontiers in genome editing
ISSN: 2673-3439
Titre abrégé: Front Genome Ed
Pays: Switzerland
ID NLM: 101775540
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
03
2022
accepted:
08
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Advancements in genome editing make possible to exploit the functions of enzymes for efficient DNA modifications with tremendous potential to treat human genetic diseases. Several nuclease genome editing strategies including Meganucleases (MNs), Zinc Finger Nucleases (ZFNs), Transcription Activator-like Effector Nucleases (TALENs) and Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated proteins (CRISPR-Cas) have been developed for the correction of genetic mutations. CRISPR-Cas has further been engineered to create nickase genome editing tools including Base editors and Prime editors with much precision and efficacy. In this review, we summarized recent improvements in nuclease and nickase genome editing approaches for the treatment of genetic diseases. We also highlighted some limitations for the translation of these approaches into clinical applications.
Identifiants
pubmed: 35958050
doi: 10.3389/fgeed.2022.892769
pii: 892769
pmc: PMC9360573
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
892769Informations de copyright
Copyright © 2022 Lu, Happi Mbakam, Song, Bendavid and Tremblay.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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