Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage.

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion of packed red blood cells containing a high amount of myeloid-related protein 14 (MRP_14) could increase the incidence of AKI after cardiac surgery. In a mouse model, MRP_14 increased the influx of neutrophils in the kidney after ischemia-reperfusion and their ability to damage tubular cells. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.

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This work was funded by the “Agence Nationale de Sécurité du Médicaments “ (ANSM 2015-A01747-42). Dr Vourc'h has received personal fees from Merck Sharp & Dohme, Pfizer, and Baxter; and has received grants from Fisher Paykel outside of the submitted work. Dr Roquilly has received grants from the French Ministry of Health during the conduct of the study; and has received personal fees from bioMerieux and Merck Sharp & Dohme outside of the submitted work. Drs Asehnoune, Roquilly and Villadangos received funding from the National Health and Medical Research Council (NHMRC) of Australia (1154502 and 1163090). Dr Ischia and Prof. Villadangos received a School of Biomedical Sciences-Department of Surgery collaborative grant from the University of Melbourne. Dr Asehnoune has received personal fees from Baxter, LFB, Edwards Lifesciences, and Fisher and Paykel outside of the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.