Long-Term Strenuous Exercise Promotes Vascular Injury by Selectively Damaging the Tunica Media: Experimental Evidence.
CACS, coronary artery calcium score
CAD, coronary artery disease
CV, cardiovascular
MMP9, matrix metalloproteinase 9
NO, nitric oxide
Phe, phenylephrine
VSMC, vascular smooth muscle cell
atherosclerosis
coronary artery disease
endurance exercise
extreme sport
vascular stiffening
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
30
09
2021
revised:
24
02
2022
accepted:
24
02
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Moderate exercise has well-founded benefits in cardiovascular health. However, increasing, yet controversial, evidence suggests that extremely trained athletes may not be protected from cardiovascular events as much as moderately trained individuals. In our rodent model, intensive but not moderate training promoted aorta and carotid stiffening and elastic lamina ruptures, tunica media thickening of intramyocardial arteries, and an imbalance between vasoconstrictor and relaxation agents. An up-regulation of angiotensin-converter enzyme, miR-212, miR-132, and miR-146b might account for this deleterious remodeling. Most changes remained after a 4-week detraining. In conclusion, our results suggest that intensive training blunts the benefits of moderate exercise.
Identifiants
pubmed: 35958697
doi: 10.1016/j.jacbts.2022.02.017
pii: S2452-302X(22)00074-2
pmc: PMC9357576
doi:
Types de publication
Journal Article
Langues
eng
Pagination
681-693Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
This work was partially supported by grants from the Instituto de Salud Carlos III (PI13/01580, PI16/00703, PI19/00443), co-funded by the European Union; CERCA program/Generalitat de Catalunya; CIBERCV (16/11/00354); and Spanish Ministry of Economy and Competitiveness (DPI2017-83721-P). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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