Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.
Coronary artery disease
Genome-wide association study
Sex differences
Sex dimorphism
Survival analysis
Journal
American heart journal plus : cardiology research and practice
ISSN: 2666-6022
Titre abrégé: Am Heart J Plus
Pays: United States
ID NLM: 101779333
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
ppublish
Résumé
Ischemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is presumed to be a major factor underlying sex differences for IHD events, including mortality. The purpose of this study was to identify sex-specific candidate genes associated with all-cause mortality among people diagnosed with coronary artery disease (CAD). We performed a sex-stratified, exploratory genome-wide association (GWAS) screen using existing data from CAD-diagnosed males ( The top GWAS hits associated with all-cause mortality among people with CAD included 8 SNPs among males and 15 among females ( We report 20 sex-specific candidate genes having suggestive association with all-cause mortality among CAD-diagnosed subjects. Findings demonstrate proof of principle for identifying sex-associated genetic factors that may help explain differential mortality risk in people with CAD. Replication and meta-analyses in larger studies with more diverse samples will strengthen future work in this area.
Sections du résumé
Background
UNASSIGNED
Ischemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is presumed to be a major factor underlying sex differences for IHD events, including mortality. The purpose of this study was to identify sex-specific candidate genes associated with all-cause mortality among people diagnosed with coronary artery disease (CAD).
Methods
UNASSIGNED
We performed a sex-stratified, exploratory genome-wide association (GWAS) screen using existing data from CAD-diagnosed males (
Results
UNASSIGNED
The top GWAS hits associated with all-cause mortality among people with CAD included 8 SNPs among males and 15 among females (
Conclusions
UNASSIGNED
We report 20 sex-specific candidate genes having suggestive association with all-cause mortality among CAD-diagnosed subjects. Findings demonstrate proof of principle for identifying sex-associated genetic factors that may help explain differential mortality risk in people with CAD. Replication and meta-analyses in larger studies with more diverse samples will strengthen future work in this area.
Identifiants
pubmed: 35959094
doi: 10.1016/j.ahjo.2022.100152
pmc: PMC9365120
mid: NIHMS1823586
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NINR NIH HHS
ID : K99 NR011054
Pays : United States
Organisme : NINR NIH HHS
ID : R00 NR011054
Pays : United States
Organisme : NHLBI NIH HHS
ID : RC2 HL101621
Pays : United States
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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