GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes.
AMPA
GABA receptor
baclofen
excitotoxicity
multiple sclerosis
muscimol
oligodendrocyte
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
03
2022
accepted:
06
06
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
Oligodendrocytes are the myelin forming cells of the central nervous system, and their vulnerability to excitotoxicity induced by glutamate contributes to the pathogenesis of neurological disorders including brain ischemia and neurodegenerative diseases, such as multiple sclerosis. In addition to glutamate receptors, oligodendrocytes express GABA receptors (GABAR) that are involved in their survival and differentiation. The interactions between glutamate and GABAergic systems are well documented in neurons, under both physiological and pathological conditions, but this potential crosstalk in oligodendrocytes has not been studied in depth. Here, we evaluated the protective effect of GABAR agonists, baclofen (GABA
Identifiants
pubmed: 35959434
doi: 10.3389/fphar.2022.897056
pii: 897056
pmc: PMC9360600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
897056Informations de copyright
Copyright © 2022 Bayón-Cordero, Ochoa-Bueno, Ruiz, Ozalla, Matute and Sánchez-Gómez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurosci. 2010 Jan 13;30(2):749-59
pubmed: 20071540
Nat Neurosci. 2015 May;18(5):674-82
pubmed: 25821912
J Anat. 2007 Jun;210(6):693-702
pubmed: 17504270
J Clin Invest. 2008 Aug;118(8):2796-807
pubmed: 18596919
Neurosci Lett. 2019 Feb 16;694:86-92
pubmed: 30476568
Neurosci Bull. 2021 Jul;37(7):1039-1050
pubmed: 33928492
J Neurochem. 2015 Apr;133(2):174-86
pubmed: 25581256
Glia. 2017 Feb;65(2):309-321
pubmed: 27796063
J Neurosci. 2011 Feb 23;31(8):2996-3006
pubmed: 21414921
Cell Death Dis. 2014 Apr 10;5:e1156
pubmed: 24722281
Curr Mol Med. 2004 Mar;4(2):113-30
pubmed: 15032708
Neuropharmacology. 2014 Apr;79:506-14
pubmed: 24412648
J Neurosci. 2015 Aug 26;35(34):12018-32
pubmed: 26311781
Sci Rep. 2019 May 22;9(1):7728
pubmed: 31118452
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8830-5
pubmed: 9238063
Front Pediatr. 2021 Feb 04;9:618052
pubmed: 33634057
FASEB J. 2008 Aug;22(8):2957-69
pubmed: 18467596
Glia. 2006 Jan 15;53(2):212-24
pubmed: 16206168
Cell Rep. 2021 May 18;35(7):109147
pubmed: 34010640
ASN Neuro. 2012 Mar 22;4(2):
pubmed: 22313331
J Neurochem. 2006 Jul;98(1):213-22
pubmed: 16606353
Molecules. 2019 Apr 22;24(8):
pubmed: 31013638
Glia. 2004 Apr 15;46(2):183-94
pubmed: 15042585
Front Cell Neurosci. 2020 Aug 21;14:256
pubmed: 32973453
Glia. 2004 Aug 15;47(3):290-8
pubmed: 15252819
Nat Neurosci. 2008 Apr;11(4):450-6
pubmed: 18311136
Nat Rev Neurosci. 2009 Jul;10(7):481-94
pubmed: 19543220
Neuromolecular Med. 2012 Dec;14(4):285-302
pubmed: 22707385
Front Mol Neurosci. 2021 Sep 01;14:726133
pubmed: 34539344
Trends Neurosci. 2001 Apr;24(4):224-30
pubmed: 11250007
Science. 1991 May 10;252(5007):851-3
pubmed: 1709304
Neuropharmacology. 2018 Jul 1;136(Pt A):68-79
pubmed: 29031577
PLoS One. 2015 Apr 13;10(4):e0124482
pubmed: 25866890
Dev Neurosci. 2016;38(1):15-26
pubmed: 26551007
Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1326-1335
pubmed: 28366876
ASN Neuro. 2013 Dec 23;5(5):e00131
pubmed: 24195677
J Biol Chem. 2013 Apr 5;288(14):9696-9709
pubmed: 23400779
Nature. 2006 Feb 23;439(7079):988-92
pubmed: 16372019
CNS Neurosci Ther. 2013 Oct;19(10):820-33
pubmed: 23889979
J Neurosci. 2003 Oct 22;23(29):9519-28
pubmed: 14573531
Methods Mol Biol. 2018;1782:357-381
pubmed: 29851012
Front Mol Neurosci. 2018 Sep 13;11:333
pubmed: 30271323
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
Eur J Pharmacol. 2007 Feb 28;557(2-3):106-14
pubmed: 17188264
Nat Med. 1998 Mar;4(3):291-7
pubmed: 9500601
Methods Mol Biol. 2018;1791:95-113
pubmed: 30006704
Neuroscience. 2020 Jul 15;439:163-180
pubmed: 31349008
Brain Res Bull. 2012 Sep 1;88(6):617-23
pubmed: 22613773
Neurobiol Dis. 1999 Dec;6(6):475-85
pubmed: 10600403
J Anat. 2011 Jul;219(1):53-64
pubmed: 21250988
Front Cell Neurosci. 2015 Apr 10;9:135
pubmed: 25914625
Int J Neurosci. 2004 Jun;114(6):695-734
pubmed: 15204061
J Neurochem. 1995 Jun;64(6):2442-8
pubmed: 7539052