Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study.
Adult
Brain Neoplasms
Colorectal Neoplasms
/ pathology
DNA Mismatch Repair
DNA-Binding Proteins
/ genetics
Female
Granulosa Cell Tumor
Humans
Immunohistochemistry
Microsatellite Instability
Mismatch Repair Endonuclease PMS2
/ metabolism
MutL Protein Homolog 1
/ genetics
MutS Homolog 2 Protein
/ genetics
Neoplastic Syndromes, Hereditary
Retrospective Studies
Journal
Applied immunohistochemistry & molecular morphology : AIMM
ISSN: 1533-4058
Titre abrégé: Appl Immunohistochem Mol Morphol
Pays: United States
ID NLM: 100888796
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
received:
24
10
2021
accepted:
24
04
2022
pubmed:
13
8
2022
medline:
11
9
2022
entrez:
12
8
2022
Statut:
ppublish
Résumé
Adult granulosa cell tumors (AGCTs) are rare ovarian malignant neoplasms; their etiopathogenetic mechanisms remain largely unelucidated. Lately, defects in mismatch repair (MMR) have been implicated in the pathogenesis of AGCTs. Demonstration of MMR deficiency in these tumors can help identify patients potentially eligible for immune checkpoint inhibition therapy. The present study was done to explore the role of MMR deficiency in the etiopathogenesis of AGCTs. This was a retrospective study conducted on histopathologically confirmed AGCT cases. MMR protein expression was evaluated by immunohistochemistry (IHC) on tissue microarrays using an antibody panel of MSH2, MSH6, MLH1, and PMS2. Of a total of 40 ovarian AGCTs evaluated for MMR deficiency, none demonstrated loss of expression of any of the 4 MMR proteins. The results of our preliminary study show that there is no association between MMR deficiency with AGCT. Nevertheless, larger multicenter studies are needed to confirm or refute this observation.
Identifiants
pubmed: 35960021
doi: 10.1097/PAI.0000000000001051
pii: 00129039-202209000-00002
doi:
Substances chimiques
DNA-Binding Proteins
0
Mismatch Repair Endonuclease PMS2
EC 3.6.1.3
MutL Protein Homolog 1
EC 3.6.1.3
MutS Homolog 2 Protein
EC 3.6.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
540-548Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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