Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil: a retrospective cohort study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 08 2022
12 08 2022
Historique:
received:
18
02
2022
accepted:
21
07
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
17
8
2022
Statut:
epublish
Résumé
The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with data obtained from a hospital-based registry. The sample consisted of 8183 ICU hospitalized patients who tested positive for SARS-CoV-2. Cox proportional models were used to evaluate the association between BMI categories and COVID-19 mortality and generalized linear models for the length of stay in the ICU. After adjusting for confounders, those in the younger group with severe obesity had an increased risk of COVID-19 mortality compared to those with normal/overweight (HR 1.27; 95% CI 1.01-1.61). An increased risk of death was also observed for patients with underweight (HR 3.74; 95% CI 1.39-10.07). For patients aged ≥ 60 year, mild/moderate obesity was associated with reduced mortality risk (HR 0.87; 95% CI 0.78-0.97). For the age group < 60 year, the length of stay in ICU for those patients with severe obesity was 35% higher compared to the normal/overweight category (e
Identifiants
pubmed: 35962010
doi: 10.1038/s41598-022-17197-w
pii: 10.1038/s41598-022-17197-w
pmc: PMC9372981
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13737Informations de copyright
© 2022. The Author(s).
Références
J Clin Endocrinol Metab. 2021 Nov 19;106(12):e5030-e5042
pubmed: 34297116
J Surg Res. 2021 Sep;265:195-203
pubmed: 33951584
Eur J Clin Invest. 2020 Oct;50(10):e13362
pubmed: 32726868
Lancet Reg Health Am. 2022 Mar;7:100167
pubmed: 35005691
Rev Bras Epidemiol. 2021 Dec 01;24:e210056
pubmed: 34877997
Respir Med. 2013 Jan;107(1):68-74
pubmed: 23085215
Obesity (Silver Spring). 2020 Sep;28(9):1595-1599
pubmed: 32445512
Epidemiol Infect. 2021 Oct 22;149:e230
pubmed: 34674789
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1149-1151
pubmed: 32668401
Epidemiol Infect. 2021 Apr 29;149:e109
pubmed: 33913410
Ann Acad Med Singap. 2020 Dec;49(12):996-1008
pubmed: 33463658
Crit Care. 2017 Feb 22;21(1):36
pubmed: 28222804
Blood. 2013 Nov 14;122(20):3415-22
pubmed: 24092932
Crit Care Med. 2017 Oct;45(10):1751-1761
pubmed: 28749855
Cad Saude Publica. 2018 May 10;34(5):e00063917
pubmed: 29768583
PLoS One. 2021 Oct 13;16(10):e0257891
pubmed: 34644316
Rev Bras Ter Intensiva. 2017 Oct-Dec;29(4):418-426
pubmed: 29211187
Obesity (Silver Spring). 2020 Jul;28(7):1178-1179
pubmed: 32314871
PLoS One. 2020 Nov 3;15(11):e0241742
pubmed: 33141836
Int J Obes (Lond). 2021 Sep;45(9):2028-2037
pubmed: 34112941
Int J Popul Data Sci. 2021 Mar 03;5(4):1411
pubmed: 34007893
Respir Med. 2021 Aug;184:106453
pubmed: 34010740
Clin Geriatr Med. 2009 Nov;25(4):643-59, viii
pubmed: 19944265
J Community Health. 2020 Dec;45(6):1270-1282
pubmed: 32918645
Int J Obes (Lond). 2018 Aug;42(8):1480-1488
pubmed: 29515210
BMJ Nutr Prev Health. 2022 Jan 19;5(1):10-18
pubmed: 35814718
Epidemiology. 1999 Jan;10(1):37-48
pubmed: 9888278
Eur J Med Res. 2020 Dec 2;25(1):64
pubmed: 33267871
Horm Metab Res. 2021 Feb;53(2):85-93
pubmed: 33395706
J Med Virol. 2021 May;93(5):2662-2674
pubmed: 33200825
Lancet. 2016 Apr 2;387(10026):1377-1396
pubmed: 27115820
Intensive Care Med. 2011 Nov;37(11):1793-9
pubmed: 21818652
Int J Epidemiol. 2016 Dec 1;45(6):1887-1894
pubmed: 28089956
Intensive Care Med. 2019 Jun;45(6):757-769
pubmed: 30888440
Obes Rev. 2020 Oct;21(10):e13095
pubmed: 32686331
Nature. 2020 Aug;584(7821):430-436
pubmed: 32640463
Sci Rep. 2021 Mar 30;11(1):7193
pubmed: 33785830
Metabolism. 2021 Apr;117:154373
pubmed: 32949592
Lancet Diabetes Endocrinol. 2021 Jun;9(6):350-359
pubmed: 33932335
Obesity (Silver Spring). 2020 Sep;28(9):1586-1589
pubmed: 32428380
Metabolism. 2020 Dec;113:154378
pubmed: 33002478
PLoS One. 2016 Sep 29;11(9):e0163677
pubmed: 27684705
Pharmacol Res. 2020 Aug;158:104927
pubmed: 32422341
Crit Care Med. 2013 Aug;41(8):1878-83
pubmed: 23685638
Front Endocrinol (Lausanne). 2020 Dec 21;11:595109
pubmed: 33408692
Expert Rev Respir Med. 2018 Sep;12(9):755-767
pubmed: 30056777