Associations of antimicrobial use with antimicrobial susceptibility at the calf level in bacteria isolated from the respiratory and digestive tracts of veal calves before slaughter.
Ampicillin
/ therapeutic use
Animals
Anti-Bacterial Agents
/ pharmacology
Anti-Infective Agents
/ therapeutic use
Cattle
Cattle Diseases
/ microbiology
Drug Resistance, Bacterial
Escherichia coli
Gastrointestinal Tract
Pasteurella multocida
Penicillins
/ therapeutic use
Red Meat
Spectinomycin
/ therapeutic use
Tetracycline
/ therapeutic use
Journal
The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
Titre abrégé: J Antimicrob Chemother
Pays: England
ID NLM: 7513617
Informations de publication
Date de publication:
30 09 2022
30 09 2022
Historique:
received:
17
11
2021
accepted:
24
06
2022
pubmed:
14
8
2022
medline:
5
10
2022
entrez:
13
8
2022
Statut:
ppublish
Résumé
Antimicrobial drugs are frequently administered in veal calves, but investigations on associations with antimicrobial susceptibility of bacteria are scarce and convey partly contradictory findings. The aim of this study was to investigate associations of antimicrobial use (AMU) during the fattening period with antimicrobial susceptibility shortly before slaughter. Detailed treatment data of 1905 veal calves from 38 farms were collected prospectively during monthly farm visits for 1 year (n = 1864 treatments, n = 535 visits); 1582 Escherichia coli, 1059 Pasteurella multocida and 315 Mannheimia haemolytica were isolated from rectal and nasopharyngeal swabs collected before slaughter and subjected to antimicrobial susceptibility testing by microdilution. Associations of antimicrobial treatments with resistant isolates were investigated at the calf level. Associations of AMU with antimicrobial resistance were observed using generalized linear models. For E. coli, the odds of being resistant were increased with increased AMU (OR 1.36 when number of treatments >1, P = 0.066). Use of tetracyclines was associated with resistance to tetracycline (OR 1.86, P < 0.001) and use of penicillins was associated with resistance to ampicillin (OR 1.66, P = 0.014). No significant associations were observed for P. multocida (use of aminoglycosides: OR 3.66 for resistance to spectinomycin, P = 0.074). For M. haemolytica, the odds of being resistant were increased with increased AMU (OR 4.63, P < 0.001), and use of tetracyclines was associated with resistance to tetracycline (OR 6.49, P < 0.001). Occurrence of resistant bacteria shortly before slaughter was associated with AMU in veal calves. Prudent and appropriate use may contribute to limit the selection of resistant bacteria on veal farms.
Identifiants
pubmed: 35962594
pii: 6664151
doi: 10.1093/jac/dkac246
pmc: PMC9525080
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Penicillins
0
Ampicillin
7C782967RD
Spectinomycin
93AKI1U6QF
Tetracycline
F8VB5M810T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2859-2866Subventions
Organisme : National Research Program 'Antimicrobial Resistance'
ID : 407240_167083
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.
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