The Effects of Methanol Extracts of Hyssopus officinalis on Model of Induced Glioblastoma Multiforme (GBM) in Rats.
Animals
Antioxidants
/ therapeutic use
Brain Neoplasms
/ drug therapy
Glioblastoma
/ drug therapy
Hyssopus Plant
Methanol
/ therapeutic use
Plant Extracts
/ pharmacology
RNA, Messenger
Rats
Superoxide Dismutase
/ genetics
Tumor Suppressor Protein p53
/ genetics
Vascular Endothelial Growth Factor A
/ genetics
Antioxidant enzymes
Apoptotic cells
Brain tumor
Cell cycle
Cell viability
Hyssopus officinalis
Tumor volume
VEGF
p21
p53
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
24
02
2022
accepted:
04
08
2022
pubmed:
14
8
2022
medline:
24
8
2022
entrez:
13
8
2022
Statut:
ppublish
Résumé
Given the complexity of pathophysiological processes of brain tumors, ineffective therapies, and high mortality rate, new therapeutic options with less toxicity are necessary. Hyssopus officinalis (hyssop) is an aromatic plant with important biological activities. The aim of this study is to assess the anti-cancer effect of hyssop extract on damages of glioblastoma multiforme. In this study, total flavonoids, phenolic content, and quantification of phenolic compound of hyssop extracts were analyzed. In vitro antioxidant properties of hyssop extract were also examined. In addition, cell viability, apoptosis, and cell cycle were evaluated in C6 glioma cell culture. In vivo, the rats were divided randomly into four main groups: intact, control, vehicle, and treatment groups. 1 × 10
Identifiants
pubmed: 35963984
doi: 10.1007/s12031-022-02058-y
pii: 10.1007/s12031-022-02058-y
doi:
Substances chimiques
Antioxidants
0
Plant Extracts
0
RNA, Messenger
0
Tumor Suppressor Protein p53
0
Vascular Endothelial Growth Factor A
0
Superoxide Dismutase
EC 1.15.1.1
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2045-2066Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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