Immunoglobulin γ chain allotypes and humoral immunity to HSV1 in Parkinson's disease.
GM allotypes
HSV1
Humoral immunity
Parkinson's disease
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 10 2022
15 10 2022
Historique:
received:
03
03
2022
revised:
06
06
2022
accepted:
03
08
2022
pubmed:
15
8
2022
medline:
15
9
2022
entrez:
14
8
2022
Statut:
ppublish
Résumé
The aim of this investigation was to determine if particular immunoglobulin GM (γ marker) alleles and genotypes were associated with Parkinson's disease (PD) and whether they contributed to the interindividual differences in the level of antibodies to herpes simplex virus type 1 (HSV1), which has been implicated in PD pathology. Using a case-control study design, 94 PD patients and 157 controls were characterized for anti-HSV1 IgG antibodies and genotyped for GM alleles expressed on IgG1 (3,17) and IgG2 (23 +, 23-). The homozygosity for the GM 3 and GM 23 alleles was significantly associated with susceptibility to PD (p = 0.004, 0.018, respectively). Also, GM 23 genotypes were significantly associated with anti-HSV1 IgG antibody levels in patients (p = 0.0021), but not in controls. These results suggest that GM genes may act as effect modifiers of the reported HSV1-PD association.
Identifiants
pubmed: 35964450
pii: S0165-5728(22)00143-6
doi: 10.1016/j.jneuroim.2022.577948
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Immunoglobulin Gm Allotypes
0
Immunoglobulin gamma-Chains
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
577948Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no competing financial interests.