Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia.
BBB breakdown
Blood-brain-barrier opening
Cardiac surgery
Heart disease
Immunoglobulin class
Seroprevalence
Serum proteins
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
06
05
2022
revised:
22
06
2022
accepted:
27
07
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.
Identifiants
pubmed: 35965838
doi: 10.1016/j.bbih.2022.100494
pii: S2666-3546(22)00084-9
pmc: PMC9372600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100494Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing financial or other interests.
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