Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor.
LFP
cerebellum
essential tremor
harmaline
motor cortex
thalamus
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
03
2022
accepted:
22
06
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Essential Tremor (ET) is a common movement disorder, characterised by a posture or movement-related tremor of the upper limbs. Abnormalities within cerebellar circuits are thought to underlie the pathogenesis of ET, resulting in aberrant synchronous oscillatory activity within the thalamo-cortical network leading to tremors. Harmaline produces pathological oscillations within the cerebellum, and a tremor that phenotypically resembles ET. However, the neural network dynamics in cerebellar-thalamo-cortical circuits in harmaline-induced tremor remains unclear, including the way circuit interactions may be influenced by behavioural state. Here, we examined the effect of harmaline on cerebello-thalamo-cortical oscillations during rest and movement. EEG recordings from the sensorimotor cortex and local field potentials (LFP) from thalamic and medial cerebellar nuclei were simultaneously recorded in awake behaving rats, alongside measures of tremor using EMG and accelerometery. Analyses compared neural oscillations before and after systemic administration of harmaline (10 mg/kg, I.P), and coherence across periods when rats were resting vs. moving. During movement, harmaline increased the 9-15 Hz behavioural tremor amplitude and increased thalamic LFP coherence with tremor. Medial cerebellar nuclei and cerebellar vermis LFP coherence with tremor however remained unchanged from rest. These findings suggest harmaline-induced cerebellar oscillations are independent of behavioural state and associated changes in tremor amplitude. By contrast, thalamic oscillations are dependent on behavioural state and related changes in tremor amplitude. This study provides new insights into the role of cerebello-thalamo-cortical network interactions in tremor, whereby neural oscillations in thalamocortical, but not cerebellar circuits can be influenced by movement and/or behavioural tremor amplitude in the harmaline model.
Identifiants
pubmed: 35965995
doi: 10.3389/fnsys.2022.899446
pmc: PMC9365993
doi:
Types de publication
Journal Article
Langues
eng
Pagination
899446Subventions
Organisme : Medical Research Council
ID : G1100626
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Woodward, Apps, Goodfellow and Cerminara.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain Res. 1973 Apr 13;53(1):81-95
pubmed: 4697252
Can J Neurol Sci. 1975 Aug;2(3):227-33
pubmed: 809126
Brain. 2015 Oct;138(Pt 10):2934-47
pubmed: 26248468
Postgrad Med J. 2005 Dec;81(962):756-62
pubmed: 16344298
Cerebellum. 2016 Jun;15(3):235-42
pubmed: 26129713
Neurosurg Focus. 2013 Nov;35(5):E1
pubmed: 24175861
Neuroimage. 2012 Apr 2;60(2):1331-9
pubmed: 22293134
Neuron. 2014 Mar 19;81(6):1389-1400
pubmed: 24656256
Mov Disord. 2005 Mar;20(3):298-305
pubmed: 15580562
Mov Disord. 2016 Aug;31(8):1230-4
pubmed: 27062434
Acta Neuropathol. 2017 Jan;133(1):121-138
pubmed: 27704282
Rev Neurosci. 2016 Dec 1;27(8):769-776
pubmed: 27559688
J Neurophysiol. 2018 May 1;119(5):1608-1628
pubmed: 29357448
Brain. 2013 Oct;136(Pt 10):3051-61
pubmed: 24030953
Sci Transl Med. 2020 Jan 15;12(526):
pubmed: 31941824
Arch Biochem Biophys. 1997 Jan 1;337(1):137-42
pubmed: 8990278
Exp Neurol. 2008 Jun;211(2):387-96
pubmed: 18394604
Neurology. 2003 Oct 14;61(7):919-25
pubmed: 14557560
Neuron. 2019 Jul 17;103(2):335-348.e5
pubmed: 31174960
Brain Struct Funct. 2020 Sep;225(7):2177-2192
pubmed: 32748090
Brain. 2013 Oct;136(Pt 10):3062-75
pubmed: 24038075
Ann Neurol. 1994 Oct;36(4):636-42
pubmed: 7944296
Mov Disord. 2013 Jun;28(6):779-86
pubmed: 23483605
Brain. 2000 Aug;123 ( Pt 8):1568-80
pubmed: 10908187
Exp Neurol. 1992 Oct;118(1):95-104
pubmed: 1397181
J Neurophysiol. 1997 Dec;78(6):3502-7
pubmed: 9405570
Parkinsonism Relat Disord. 2018 Jun;51:24-29
pubmed: 29482925
Brain. 2014 Dec;137(Pt 12):3142-8
pubmed: 25367027
J Neurosci Methods. 2010 Aug 15;191(1):94-100
pubmed: 20566351
Cerebellum. 2017 Apr;16(2):473-482
pubmed: 27726094
Tremor Other Hyperkinet Mov (N Y). 2018 Oct 9;8:587
pubmed: 30402338
J Comp Neurol. 1987 Mar 22;257(4):553-77
pubmed: 2826551
J Neurosci. 2014 Oct 22;34(43):14475-83
pubmed: 25339758
Elife. 2020 Mar 17;9:
pubmed: 32180549
Tremor Other Hyperkinet Mov (N Y). 2012;2:
pubmed: 23440018
Front Cell Neurosci. 2019 Oct 15;13:448
pubmed: 31680866
Mov Disord. 1994 Mar;9(2):193-6
pubmed: 8196682
Neuron. 2020 Nov 11;108(3):512-525.e4
pubmed: 32783881
Front Integr Neurosci. 2017 Oct 16;11:27
pubmed: 29089872
Neuroscience. 2002;113(1):137-43
pubmed: 12123692
Mov Disord. 2009 Aug 15;24(11):1629-35
pubmed: 19514010
Nat Med. 2008 Jan;14(1):75-80
pubmed: 18157140
Ther Adv Neurol Disord. 2013 Jul;6(4):229-36
pubmed: 23858326
J Neurol Neurosurg Psychiatry. 2011 Sep;82(9):1038-40
pubmed: 20802031
Mov Disord. 2009 Mar 15;24(4):626-7
pubmed: 19185016
J Neurophysiol. 2021 Jul 1;126(1):112-122
pubmed: 34107223
Eur J Neurol. 2012 Apr;19(4):625-30
pubmed: 22136494
Brain. 2017 Jul 1;140(7):1977-1986
pubmed: 28459950
J Comp Neurol. 2021 Jan;529(1):187-220
pubmed: 32374027
J Comp Neurol. 1998 Mar 2;392(1):115-33
pubmed: 9482236
Neuron. 2009 Jan 15;61(1):126-39
pubmed: 19146818
Mov Disord. 2010 Apr 15;25(5):534-41
pubmed: 20175185
J Neurophysiol. 2005 Aug;94(2):1236-51
pubmed: 16061491
Brain. 2018 Jun 1;141(6):1770-1781
pubmed: 29701820
Front Neurol. 2013 May 10;4:51
pubmed: 23717300
J Neurol Sci. 1993 Jan;114(1):45-8
pubmed: 8433096
Sci Rep. 2016 Oct 21;6:35689
pubmed: 27767085
J Comp Neurol. 2011 Apr 1;519(5):874-99
pubmed: 21280042
J Neurosci. 2015 Jan 14;35(2):795-806
pubmed: 25589772
Exp Brain Res. 1971 May 26;112(4):331-53
pubmed: 5579566
Brain Res. 2006 Oct 18;1115(1):213-6
pubmed: 16920079
Exp Brain Res. 1984;57(1):128-37
pubmed: 6519221
Neuroscience. 1981;6(8):1625-31
pubmed: 6267509
Brain. 2014 Dec;137(Pt 12):3149-59
pubmed: 25273997
Mov Disord. 2018 Jan;33(1):75-87
pubmed: 29193359
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S162-5
pubmed: 26522219
Brain. 2007 Jun;130(Pt 6):1538-51
pubmed: 17468116
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7164-9
pubmed: 15103021
J Physiol Paris. 2006 Jan;99(1):3-7
pubmed: 16054347
Exp Brain Res. 1973 Aug 31;18(1):69-87
pubmed: 4746753
Neuropharmacology. 2011 Sep;61(4):715-23
pubmed: 21640732
Exp Brain Res. 1981;42(3-4):383-91
pubmed: 7238678
J Neurophysiol. 2005 Jan;93(1):117-27
pubmed: 15317839
Cereb Cortex. 2014 Jan;24(1):81-97
pubmed: 23042738
Ann Neurol. 1996 May;39(5):650-8
pubmed: 8619551
J Physiol. 1984 Jun;351:411-32
pubmed: 6747870
Food Chem Toxicol. 2010 Mar;48(3):839-45
pubmed: 20036304
Tremor Other Hyperkinet Mov (N Y). 2018 Mar 13;8:532
pubmed: 29686939
J Neurophysiol. 1998 Sep;80(3):1598-604
pubmed: 9744967
Adv Pharmacol. 1998;42:292-6
pubmed: 9327898
Neuroscience. 2020 Mar 1;429:106-118
pubmed: 31935489
J Transl Med. 2008 Nov 26;6:71
pubmed: 19036142
Heliyon. 2021 Oct 04;7(10):e08119
pubmed: 34660929
Brain. 2001 Nov;124(Pt 11):2278-86
pubmed: 11673328
J Neurophysiol. 2002 Aug;88(2):771-82
pubmed: 12163529
J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):273-6
pubmed: 9489548
Neuron. 2018 Oct 10;100(1):46-60.e7
pubmed: 30308171