Ectopic fat is associated with cardiac remodeling-A comprehensive assessment of regional fat depots in type 2 diabetes using multi-parametric MRI.
cardiac remodeling
ectopic fat
left ventricular diastolic function
left ventricular structure
magnetic resonance imaging
type 2 diabetes
visceral fat
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
11
2021
accepted:
30
06
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Different regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls. From the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue). Compared to the control group, the T2D group had increased: visceral adipose tissue volume index ( Ectopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue.
Sections du résumé
Background
UNASSIGNED
Different regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls.
Methods
UNASSIGNED
From the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue).
Results
UNASSIGNED
Compared to the control group, the T2D group had increased: visceral adipose tissue volume index (
Conclusions
UNASSIGNED
Ectopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue.
Identifiants
pubmed: 35966535
doi: 10.3389/fcvm.2022.813427
pmc: PMC9366177
doi:
Types de publication
Journal Article
Langues
eng
Pagination
813427Informations de copyright
Copyright © 2022 Edin, Ekstedt, Scheffel, Karlsson, Swahn, Östgren, Engvall, Ebbers, Leinhard, Lundberg and Carlhäll.
Déclaration de conflit d'intérêts
Authors MK and OL are employees of AMRA Medical AB. Authors OL and PL are stockholders in AMRA Medical AB. Author ME reports personal fees from Advisory Board AMRA Medical AB. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Cardiovasc Imaging. 2021 Nov 30;:
pubmed: 34846618
Hepatology. 2008 Jan;47(1):51-8
pubmed: 17955548
J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9
pubmed: 19022158
Eur Heart J. 2016 Feb 1;37(5):449-54
pubmed: 26497163
Liver Int. 2020 May;40(5):1069-1078
pubmed: 32087038
Am J Clin Nutr. 2007 Jul;86(1):82-91
pubmed: 17616766
Gastroenterology. 2017 Jul;153(1):53-55.e7
pubmed: 28286210
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):233-70
pubmed: 25712077
J Magn Reson. 1997 Nov;129(1):35-43
pubmed: 9405214
N Engl J Med. 1987 Oct 22;317(17):1098
pubmed: 3657876
Cardiovasc Diabetol. 2018 Jun 12;17(1):88
pubmed: 29895299
Eur Radiol. 2015 Nov;25(11):3372-81
pubmed: 25925354
Int J Cardiovasc Imaging. 2016 Feb;32(2):291-299
pubmed: 26424492
J Hepatol. 2006 Jun;44(6):1167-74
pubmed: 16618517
Diabetes Care. 2012 Feb;35(2):389-95
pubmed: 22210573
J Clin Endocrinol Metab. 2006 Nov;91(11):4689-95
pubmed: 16926257
MAGMA. 2001 May;12(2-3):141-52
pubmed: 11390270
BMC Med Imaging. 2010 Jan 11;10:1
pubmed: 20064248
Am J Med. 2018 Jun;131(6):684-692.e12
pubmed: 29518370
Circ Cardiovasc Imaging. 2013 Sep;6(5):800-7
pubmed: 23929898
J Intern Med. 2015 Dec;278(6):645-59
pubmed: 26096600
Hepatol Res. 2017 May;47(6):522-532
pubmed: 27379875
Gut. 2017 Jun;66(6):1138-1153
pubmed: 28314735
Eur Heart J Cardiovasc Imaging. 2020 Mar 1;21(3):273-281
pubmed: 31722392
Nat Rev Cardiol. 2017 Oct;14(10):591-602
pubmed: 28492288
Ann Med. 2012 Feb;44(1):82-92
pubmed: 20964583
J Am Heart Assoc. 2018 Dec 4;7(23):e009975
pubmed: 30571602
Int J Cardiol. 2007 Feb 7;115(2):272-3
pubmed: 16759715
Eur Heart J. 2015 Jul 14;36(27):1718-27, 1727a-1727c
pubmed: 25888006
Metabolism. 2017 Feb;67:80-89
pubmed: 28081781
PLoS One. 2018 Feb 7;13(2):e0192495
pubmed: 29415060
Nat Rev Endocrinol. 2015 Jun;11(6):363-71
pubmed: 25850659
Nutr Metab Cardiovasc Dis. 2015 Jul;25(7):667-76
pubmed: 26033394
Obesity (Silver Spring). 2019 Jul;27(7):1190-1199
pubmed: 31094076
Lancet Diabetes Endocrinol. 2019 Sep;7(9):715-725
pubmed: 31301983
J Magn Reson Imaging. 2015 Jun;41(6):1558-69
pubmed: 25111561
Cardiovasc Diabetol. 2020 May 29;19(1):70
pubmed: 32471503
Circulation. 2007 Jul 3;116(1):39-48
pubmed: 17576866
J Magn Reson Imaging. 2011 Jun;33(6):1390-8
pubmed: 21591008
JACC Cardiovasc Imaging. 2017 Sep;10(9):1016-1027
pubmed: 28330662
Circulation. 2011 Dec 13;124(24):e837-41
pubmed: 22156000
J Magn Reson Imaging. 2019 Jul;50(1):325-333
pubmed: 30637926
Med Image Anal. 2005 Dec;9(6):594-604
pubmed: 15896995
Magn Reson Imaging. 1994;12(3):487-95
pubmed: 8007779