Folic acid and zinc improve hyperuricemia by altering the gut microbiota of rats with high-purine diet-induced hyperuricemia.
folic acid
gut microbiota
hyperuricemia
uric acid
zinc
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
04
2022
accepted:
08
07
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
A high-purine diet can cause hyperuricemia and destroy the microbial composition of the gut microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate hyperuricemia. However, whether the underlying mechanisms are associated with the regulation of the gut microbiota remain unknown. To explore alterations of the gut microbiota related to folic acid and zinc treatment in rats with hyperuricemia in our study. A hyperuricemic rat model was established with a high-purine diet. The effects of folic acid and zinc on uric acid levels were evaluated. Alterations of the gut microbiota related to hyperuricemia and the treatments were evaluated by sequencing using the Illumina MiSeq system. The results demonstrated that uric acid levels dropped observably, and the activities of adenosine deaminase (ADA) and xanthine oxidase (XOD) were downregulated after folic acid or zinc intervention. 16S rRNA gene sequencing-based gut microbiota analysis revealed that folic acid and zinc enhanced the abundance of probiotic bacteria and reduced that of pathogenic bacteria, thus improving intestinal barrier function. PICRUST analysis indicated that folic acid and zinc restored gut microbiota metabolism. These findings indicate that folic acid and zinc ameliorate hyperuricemia by inhibiting uric acid biosynthesis and stimulating uric acid excretion by modulating the gut microbiota. Thus, folic acid and zinc may be new and safe therapeutic agents to improve hyperuricemia.
Identifiants
pubmed: 35966674
doi: 10.3389/fmicb.2022.907952
pmc: PMC9372534
doi:
Types de publication
Journal Article
Langues
eng
Pagination
907952Informations de copyright
Copyright © 2022 Sun, Wen, Guan, Li, Luo, Li, Wei and Qiu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Nephrol. 2019 Dec;15(12):767-775
pubmed: 31296965
Kidney Int. 2021 Jan;99(1):12-14
pubmed: 33390224
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
PPAR Res. 2007;2007:36092
pubmed: 18274627
Gerontology. 2008;54(4):238-43
pubmed: 18367828
Biomed Res Int. 2015;2015:127596
pubmed: 25629033
Biomed Pharmacother. 2020 Nov;131:110719
pubmed: 33152909
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Front Microbiol. 2018 Sep 19;9:2233
pubmed: 30283432
Comb Chem High Throughput Screen. 2022;25(8):1294-1303
pubmed: 34053424
Sci Rep. 2014 Jan 20;4:3755
pubmed: 24441388
Nephron. 1975;14(1):7-20
pubmed: 1124137
Sci Rep. 2018 Sep 18;8(1):13974
pubmed: 30228361
Bioorg Med Chem. 2011 Jan 1;19(1):211-20
pubmed: 21163661
Nat Rev Microbiol. 2011 Apr;9(4):279-90
pubmed: 21407244
J Clin Med. 2018 Aug 11;7(8):
pubmed: 30103487
Am J Med. 2015 Jun;128(6):653.e7-653.e16
pubmed: 25660249
Bioinformatics. 2014 Nov 1;30(21):3123-4
pubmed: 25061070
Inflamm Res. 2021 Jan;70(1):127-137
pubmed: 33074353
Biochimie. 2015 Sep;116:17-23
pubmed: 26133655
Joint Bone Spine. 2011 Jan;78(1):35-40
pubmed: 20472486
Nat Biotechnol. 2020 Jun;38(6):685-688
pubmed: 32483366
Animal. 2014 Nov;8(11):1777-87
pubmed: 25046106
Phytomedicine. 2021 Jan;80:153374
pubmed: 33075645
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Biomed Pharmacother. 2020 Dec;132:110765
pubmed: 33120237
PeerJ. 2020 Mar 6;8:e8664
pubmed: 32185104
Cardiol Clin. 2021 Aug;39(3):365-376
pubmed: 34247750
Nutrients. 2018 May 05;10(5):
pubmed: 29734733
Crit Rev Food Sci Nutr. 2019;59(9):1433-1455
pubmed: 29278921
Lipids Health Dis. 2017 Mar 23;16(1):62
pubmed: 28335773
J Adv Res. 2017 Sep;8(5):471-474
pubmed: 28748113
Cell Host Microbe. 2017 May 10;21(5):603-610.e3
pubmed: 28494241
J Med Food. 2014 Nov;17(11):1214-21
pubmed: 25314375
ISME J. 2014 Jul;8(7):1403-17
pubmed: 24500617
Sci Rep. 2016 Feb 08;6:20602
pubmed: 26852926
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
Food Funct. 2021 Jun 21;12(12):5637-5649
pubmed: 34018499
Rheumatology (Oxford). 2010 Nov;49(11):2010-5
pubmed: 20627967
Mol Med Rep. 2019 Oct;20(4):3292-3300
pubmed: 31432190
Infect Immun. 2013 Apr;81(4):1129-39
pubmed: 23340314
Nutr Metab (Lond). 2017 Jun 13;14:38
pubmed: 28630638
Transl Res. 2017 Jan;179:204-222
pubmed: 27591027
Clin Rheumatol. 2017 Dec;36(12):2637-2644
pubmed: 28980141
Biol Trace Elem Res. 2015 Dec;168(2):411-20
pubmed: 25987270
Curr Diab Rep. 2018 Mar 1;18(4):18
pubmed: 29497863
Curr Opin Rheumatol. 2014 Mar;26(2):176-85
pubmed: 24419747
Food Funct. 2021 Oct 4;12(19):9030-9042
pubmed: 34382991
Clin Rheumatol. 2020 Dec;39(12):3777-3785
pubmed: 32458239