The importance of taking ART appropriately in children and adolescents with HIV-1 to reach the highest capacity of immune function later in life.
HIV-1
T cell receptor clonal expansions
T cell receptor repertoires
antiretroviral therapy (ART)
children
high throughout sequencing
immune reconstitution
thymic output
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
01
2022
accepted:
28
06
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
17
8
2022
Statut:
epublish
Résumé
Current antiretroviral therapy (ART) guidelines recommend treating all children with HIV-1 infection. This has changed from the broader use of ART to treat children to improve morbidity and minimise mortality. However, prior to current recommendations, not everyone with HIV-1 received timely treatment. What happens to the paediatric immune system when HIV-1 replication is not appropriately supressed remains unclear. 11 samples from adolescents with HIV-1 on ART and uninfected controls in the UK, aged 12-25 years, were examined; overall, adolescents with CD4
Identifiants
pubmed: 35967315
doi: 10.3389/fimmu.2022.860316
pmc: PMC9364750
doi:
Substances chimiques
Anti-Retroviral Agents
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
860316Subventions
Organisme : NIAID NIH HHS
ID : P30 AI073961
Pays : United States
Informations de copyright
Copyright © 2022 Sandgaard, Gkouleli, Attenborough, Adams, Gibbons, Holm, Eisen, Baxendale, De Rossi, Pahwa, Chain, Gkazi and Klein.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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