Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk.
breast milk
infant
lactopontin
osteopontin
preterm
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
06
2022
accepted:
13
07
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Lactopontin (LPN) in breast milk, also known as milk osteopontin is thought to play a myriad of important roles in infants when they are immature. The purpose of the present study was to examine the longitudinal changes in LPN concentrations in term and preterm milk, and elucidate the links between maternal characteristics, LPN levels, and child growth in a birth cohort. 131 mothers who delivered term, moderate-late preterm (MPT), very preterm (VPT), and extremely preterm (EPT) infants were included, milk samples were collected at 7, 14, 28, and 120 days postpartum. LPN concentration was determined by multiple reaction monitoring (MRM) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Our results indicated that LPN change over time of VPT ( LPN levels in breast milk are related to maternal factors, and differences in LPN levels may affect the growth of infants. As milk is a critical part in the mother-breastmilk-infant "triad," the association between maternal-infant factors and milk LPN levels warrants further study.
Sections du résumé
Background
UNASSIGNED
Lactopontin (LPN) in breast milk, also known as milk osteopontin is thought to play a myriad of important roles in infants when they are immature. The purpose of the present study was to examine the longitudinal changes in LPN concentrations in term and preterm milk, and elucidate the links between maternal characteristics, LPN levels, and child growth in a birth cohort.
Methods
UNASSIGNED
131 mothers who delivered term, moderate-late preterm (MPT), very preterm (VPT), and extremely preterm (EPT) infants were included, milk samples were collected at 7, 14, 28, and 120 days postpartum. LPN concentration was determined by multiple reaction monitoring (MRM) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
Results
UNASSIGNED
Our results indicated that LPN change over time of VPT (
Conclusion
UNASSIGNED
LPN levels in breast milk are related to maternal factors, and differences in LPN levels may affect the growth of infants. As milk is a critical part in the mother-breastmilk-infant "triad," the association between maternal-infant factors and milk LPN levels warrants further study.
Identifiants
pubmed: 35967792
doi: 10.3389/fnut.2022.962802
pmc: PMC9372532
doi:
Types de publication
Journal Article
Langues
eng
Pagination
962802Informations de copyright
Copyright © 2022 Zhu, Yu, Wang, Bai, Lai, Tong and Xing.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Crit Rev Oral Biol Med. 2000;11(3):279-303
pubmed: 11021631
Biochem J. 2005 Aug 15;390(Pt 1):285-92
pubmed: 15869464
Food Chem. 2021 May 1;343:128489
pubmed: 33153809
Int J Gynaecol Obstet. 2020 Jul;150(1):31-33
pubmed: 32524596
Mol Syst Biol. 2008;4:222
pubmed: 18854821
Nutrients. 2021 Jul 31;13(8):
pubmed: 34444830
J Pediatr Gastroenterol Nutr. 2018 Aug;67(2):250-256
pubmed: 29668569
Mol Biol Cell. 1992 Oct;3(10):1169-80
pubmed: 1421573
BMC Genomics. 2016 Jul 20;17 Suppl 6:487
pubmed: 27454254
J Acad Nutr Diet. 2019 Feb;119(2):323-339
pubmed: 29871835
Curr Opin Clin Nutr Metab Care. 2016 May;19(3):214-9
pubmed: 27504516
J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):650-7
pubmed: 26465791
Am J Physiol Gastrointest Liver Physiol. 2019 Jul 1;317(1):G67-G77
pubmed: 31091150
Pediatr Res. 2017 Jul;82(1):63-71
pubmed: 28355198
J Biol Chem. 2012 Feb 3;287(6):3788-97
pubmed: 22179617
Science. 2020 Mar 6;367(6482):1070-1072
pubmed: 32139527
Am J Perinatol. 2016 Feb;33(3):318-28
pubmed: 26799967
Biochem J. 2008 Apr 1;411(1):53-61
pubmed: 18072945
BMC Pediatr. 2013 Apr 20;13:59
pubmed: 23601190
Clin Exp Immunol. 2004 Oct;138(1):47-53
pubmed: 15373904
J Proteomics. 2016 Sep 16;147:40-47
pubmed: 26877185
J Dairy Sci. 2009 Nov;92(11):5378-85
pubmed: 19841198
J Proteome Res. 2012 Mar 2;11(3):1696-714
pubmed: 22309230
J Struct Biol. 2014 Mar;185(3):383-96
pubmed: 24316224
J Dent Res. 2015 Dec;94(12):1638-45
pubmed: 26341976
Br J Nutr. 2011 Jan;105(1):44-53
pubmed: 20723273
Pediatr Res. 2019 Mar;85(4):502-505
pubmed: 30636771
J Perinatol. 2020 Sep;40(9):1286-1295
pubmed: 32277164
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):426-30
pubmed: 1729712
Food Funct. 2017 Oct 18;8(10):3769-3782
pubmed: 28959809
Biochim Biophys Acta. 1989 Jun 13;996(1-2):43-8
pubmed: 2736258
Int J Mol Sci. 2021 Jul 29;22(15):
pubmed: 34360914
Nutrients. 2020 Sep 15;12(9):
pubmed: 32942688
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:156-68
pubmed: 26279007
J Nutr. 2021 Apr 8;151(4):826-839
pubmed: 33693758
Semin Immunopathol. 2020 Aug;42(4):375-376
pubmed: 32960305