Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden.

Atrial Fibrillation / complications Comorbidity Female Humans Male Risk Assessment Risk Factors Stroke / epidemiology
anti-arrhythmia agents atrial fibrillation atrial fibrillation ablation comorbidity death stroke

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
13 09 2022
Historique:
pubmed: 16 8 2022
medline: 15 9 2022
entrez: 15 8 2022
Statut: ppublish

Résumé

The randomized EAST-AFNET4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial-Atrial Fibrillation Network) demonstrated that early rhythm control (ERC) reduces adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. The effectiveness and safety of ERC in patients with multiple cardiovascular comorbidities is not known. These prespecified subanalyses of EAST-AFNET4 compared the effectiveness and safety of ERC with usual care (UC) stratified into patients with higher (CHA EAST-AFNET4 randomized 1093 patients with CHA Patients with recently diagnosed atrial fibrillation and CHA URL: https://www. gov; Unique identifier: NCT01288352. URL: https://www.clinicaltrialsregister.eu; Unique identifier: 2010-021258-20. URL: https://www.isrctn.com/; Unique identifier: ISRCTN04708680.

Sections du résumé

BACKGROUND
The randomized EAST-AFNET4 (Early Treatment of Atrial Fibrillation for Stroke Prevention Trial-Atrial Fibrillation Network) demonstrated that early rhythm control (ERC) reduces adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. The effectiveness and safety of ERC in patients with multiple cardiovascular comorbidities is not known.
METHODS
These prespecified subanalyses of EAST-AFNET4 compared the effectiveness and safety of ERC with usual care (UC) stratified into patients with higher (CHA
RESULTS
EAST-AFNET4 randomized 1093 patients with CHA
CONCLUSIONS
Patients with recently diagnosed atrial fibrillation and CHA
REGISTRATION
URL: https://www.
CLINICALTRIALS
gov; Unique identifier: NCT01288352. URL: https://www.clinicaltrialsregister.eu; Unique identifier: 2010-021258-20. URL: https://www.isrctn.com/; Unique identifier: ISRCTN04708680.

Identifiants

DOI: 10.1161/CIRCULATIONAHA.122.060274 PMID: 35968706
pubmed: 35968706
doi: 10.1161/CIRCULATIONAHA.122.060274
doi:

Banques de données

ClinicalTrials.gov
['NCT01288352']

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

836-847

Commentaires et corrections

Type : CommentIn

Auteurs

Andreas Rillig (A)

Department of Cardiology, University Heart and Vascular Center (A.R., K.B., A.M., P.K.), University Medical Center Hamburg-Eppendorf, Germany.
German Center for Cardiovascular Research, Partner Site Hamburg/Luebeck/Kiel, Germany (A.R., K.-H.K., A.M., K.W., P.K.).
ORCID: 0000-0003-3457-0936

Katrin Borof (K)

Department of Cardiology, University Heart and Vascular Center (A.R., K.B., A.M., P.K.), University Medical Center Hamburg-Eppendorf, Germany.

Günter Breithardt (G)

Atrial Fibrillation Network (AFNET), Münster, Germany (G.B., A.G., K.-H.K., K.W., P.K.).
Department of Cardiology II (Electrophysiology), University Hospital Münster, Germany (G.B.).
ORCID: 0000-0001-7574-8900

A John Camm (AJ)

Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St George's University of London, UK (A.J.C.).
ORCID: 0000-0002-2536-2871

Harry J G M Crijns (HJGM)

Department of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute, The Netherlands (H.J.G.M.C.).
ORCID: 0000-0003-1073-5337

Andreas Goette (A)

Atrial Fibrillation Network (AFNET), Münster, Germany (G.B., A.G., K.-H.K., K.W., P.K.).
St Vincenz Hospital, Paderborn, Germany (A.G.).
Working Group of Molecular Electrophysiology, University Hospital Magdeburg, Germany (A.G.).

Karl-Heinz Kuck (KH)

German Center for Cardiovascular Research, Partner Site Hamburg/Luebeck/Kiel, Germany (A.R., K.-H.K., A.M., K.W., P.K.).
Atrial Fibrillation Network (AFNET), Münster, Germany (G.B., A.G., K.-H.K., K.W., P.K.).
LANS Cardio, Hamburg, Germany (K.-H.K.).
ORCID: 0000-0003-2649-3870

Andreas Metzner (A)

Department of Cardiology, University Heart and Vascular Center (A.R., K.B., A.M., P.K.), University Medical Center Hamburg-Eppendorf, Germany.
German Center for Cardiovascular Research, Partner Site Hamburg/Luebeck/Kiel, Germany (A.R., K.-H.K., A.M., K.W., P.K.).

Panos Vardas (P)

Heart Sector, Hygeia Hospitals Group, Athens, Greece (P.V.).

Eik Vettorazzi (E)

Institute of Medical Biometry and Epidemiology (E.V., K.W., A.Z.), University Medical Center Hamburg-Eppendorf, Germany.
ORCID: 0000-0002-3737-6402

Karl Wegscheider (K)

Institute of Medical Biometry and Epidemiology (E.V., K.W., A.Z.), University Medical Center Hamburg-Eppendorf, Germany.
German Center for Cardiovascular Research, Partner Site Hamburg/Luebeck/Kiel, Germany (A.R., K.-H.K., A.M., K.W., P.K.).
Atrial Fibrillation Network (AFNET), Münster, Germany (G.B., A.G., K.-H.K., K.W., P.K.).
ORCID: 0000-0003-2974-3142

Antonia Zapf (A)

Institute of Medical Biometry and Epidemiology (E.V., K.W., A.Z.), University Medical Center Hamburg-Eppendorf, Germany.
ORCID: 0000-0002-8467-0508

Paulus Kirchhof (P)

Department of Cardiology, University Heart and Vascular Center (A.R., K.B., A.M., P.K.), University Medical Center Hamburg-Eppendorf, Germany.
German Center for Cardiovascular Research, Partner Site Hamburg/Luebeck/Kiel, Germany (A.R., K.-H.K., A.M., K.W., P.K.).
Atrial Fibrillation Network (AFNET), Münster, Germany (G.B., A.G., K.-H.K., K.W., P.K.).
Institute of Cardiovascular Sciences, University of Birmingham, UK (P.K.).
ORCID: 0000-0002-1881-0197

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Early Rhythm Control in Patients With Atrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Early Rhythm Control in Patients With Atrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early Rhythm Control in Patients With Atrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Early Rhythm Control in Patients With Atrial...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Early Rhythm Control in Patients With Atrial...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Early Rhythm Control in Patients With Atrial...