Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner.
local field potentials
motor cortex
neural manifolds
neural populations
neuroscience
rhesus macaque
single neurons
somatosensory cortex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
18
08
2021
accepted:
02
08
2022
pubmed:
16
8
2022
medline:
15
9
2022
entrez:
15
8
2022
Statut:
epublish
Résumé
The spiking activity of populations of cortical neurons is well described by the dynamics of a small number of population-wide covariance patterns, whose activation we refer to as 'latent dynamics'. These latent dynamics are largely driven by the same correlated synaptic currents across the circuit that determine the generation of local field potentials (LFPs). Yet, the relationship between latent dynamics and LFPs remains largely unexplored. Here, we characterised this relationship for three different regions of primate sensorimotor cortex during reaching. The correlation between latent dynamics and LFPs was frequency-dependent and varied across regions. However, for any given region, this relationship remained stable throughout the behaviour: in each of primary motor and premotor cortices, the LFP-latent dynamics correlation profile was remarkably similar between movement planning and execution. These robust associations between LFPs and neural population latent dynamics help bridge the wealth of studies reporting neural correlates of behaviour using either type of recordings.
Identifiants
pubmed: 35968845
doi: 10.7554/eLife.73155
pii: 73155
pmc: PMC9470163
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.xd2547dkt']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS074044
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS092356
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095251
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS053603
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007418
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS086749
Pays : United States
Informations de copyright
© 2022, Gallego-Carracedo et al.
Déclaration de conflit d'intérêts
CG, MP, RC, LM, JG No competing interests declared
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