Calciphylaxis and Kidney Disease: A Review.
Calciphylaxis
calcific uremic arteriolopathy
calcium apatite
dermatologic lesion
dialysis
end-stage renal disease (ESRD)
microvascular calcification
pain management
review
sodium thiosulfate (STS)
vasculopathy
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
09
02
2022
accepted:
28
06
2022
pubmed:
16
8
2022
medline:
25
1
2023
entrez:
15
8
2022
Statut:
ppublish
Résumé
Calciphylaxis is a life-threatening complication most often associated with chronic kidney disease that occurs as a result of the deposition of calcium in dermal and adipose microvasculature. However, this condition may also be seen in patients with acute kidney injury. The high morbidity and mortality rates associated with calciphylaxis highlight the importance to correctly diagnose and treat this condition. However, calciphylaxis remains a diagnosis that may be clinically challenging to make. Here, we review the literature on uremic calciphylaxis with a focus on its pathophysiology, clinical presentation, advances in diagnostic tools, and treatment strategies. We also discuss the unique histopathological features of calciphylaxis and contrast it with those of other forms of general vessel calcification. This review emphasizes the need for multidisciplinary collaboration including nephrology, dermatology, and palliative care to ultimately provide the best possible care to patients with calciphylaxis.
Identifiants
pubmed: 35970430
pii: S0272-6386(22)00849-6
doi: 10.1053/j.ajkd.2022.06.011
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-239Informations de copyright
Copyright © 2022. Published by Elsevier Inc.