Diterpenes from Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui (Pinaceae) and their protective effects in LPS-treated BEAS-2B cells.
BEAS-2B
Diterpene
Pinaceae
Pine resin
Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui
Protective effect
Rosins A−H
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
08
05
2022
revised:
24
07
2022
accepted:
29
07
2022
pubmed:
16
8
2022
medline:
12
10
2022
entrez:
15
8
2022
Statut:
ppublish
Résumé
Eight previously undescribed diterpenoids, rosins A-H, and nine known diterpenoids were isolated from the resin from Pinus kesiya var. langbianensis (A.Chev.) Gaussen ex Bui (Pinaceae) extracted with 95% ethanol. Their structures were determined by nuclear magnetic resonance spectroscopy, mass spectrometry, J-based configuration analysis (JBCA), NOESY spectra, calculated NMR chemical shifts and electronic circular dichroic (ECD) spectra. All compounds were evaluated for their protective effects in LPS-treated human normal lung epithelial cells (BEAS-2B), and the cell viability was significantly increased after treatment with compounds 5, 10, 12, or 15 at a concentration of 10 μM.
Identifiants
pubmed: 35970437
pii: S0031-9422(22)00276-X
doi: 10.1016/j.phytochem.2022.113360
pii:
doi:
Substances chimiques
Diterpenes
0
Lipopolysaccharides
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113360Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.