Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
17
02
2022
accepted:
04
08
2022
entrez:
15
8
2022
pubmed:
16
8
2022
medline:
18
8
2022
Statut:
epublish
Résumé
Regional connectivity and land travel have been identified as important drivers of SARS-CoV-2 transmission. However, the generalizability of this finding is understudied outside of well-sampled, highly connected regions. In this study, we investigated the relative contributions of regional and intercontinental connectivity to the source-sink dynamics of SARS-CoV-2 for Jordan and the Middle East. By integrating genomic, epidemiological and travel data we show that the source of introductions into Jordan was dynamic across 2020, shifting from intercontinental seeding in the early pandemic to more regional seeding for the travel restrictions period. We show that land travel, particularly freight transport, drove introduction risk during the travel restrictions period. High regional connectivity and land travel also drove Jordan's export risk. Our findings emphasize regional connectedness and land travel as drivers of transmission in the Middle East.
Identifiants
pubmed: 35970983
doi: 10.1038/s41467-022-32536-1
pii: 10.1038/s41467-022-32536-1
pmc: PMC9376901
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4784Subventions
Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI135992
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151378
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002550
Pays : United States
Organisme : CIHR
ID : OV3 170632
Pays : Canada
Organisme : NIAID NIH HHS
ID : U01 AI151812
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Gene. 2021 Oct 30;801:145843
pubmed: 34274478
Virus Evol. 2018 Jun 08;4(1):vey016
pubmed: 29942656
Microb Genom. 2021 Jun;7(6):
pubmed: 34156923
Science. 2021 Feb 12;371(6530):708-712
pubmed: 33419936
Pathogens. 2021 Mar 05;10(3):
pubmed: 33807556
Lancet. 2004 Mar 20;363(9413):938-47
pubmed: 15043961
Cell Res. 2021 Jun;31(6):717-719
pubmed: 33737693
Nat Med. 2021 Mar;27(3):440-446
pubmed: 33531709
Nat Commun. 2020 Oct 9;11(1):5110
pubmed: 33037213
PLoS Comput Biol. 2009 Sep;5(9):e1000520
pubmed: 19779555
Nat Commun. 2021 Oct 1;12(1):5769
pubmed: 34599175
BMJ Glob Health. 2021 Mar;6(3):
pubmed: 33722793
Nature. 2021 Jul;595(7869):713-717
pubmed: 34192736
J Math Biol. 2008 Mar;56(3):391-412
pubmed: 17874105
J Mol Evol. 1985;22(2):160-74
pubmed: 3934395
Cell. 2021 Jan 7;184(1):64-75.e11
pubmed: 33275900
Syst Biol. 2018 Sep 1;67(5):901-904
pubmed: 29718447
Science. 2020 Oct 30;370(6516):564-570
pubmed: 32912998
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Virus Evol. 2018 Jan 08;4(1):vex042
pubmed: 29340210
Nat Commun. 2020 Nov 2;11(1):5518
pubmed: 33139704
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8
pubmed: 15980494
Nat Commun. 2021 Sep 29;12(1):5705
pubmed: 34588460
Bioinformatics. 2012 Oct 1;28(19):2520-2
pubmed: 22908215
Nat Hum Behav. 2021 Apr;5(4):529-538
pubmed: 33686204
Confl Health. 2020 Feb 18;14:9
pubmed: 32099579
Mol Biol Evol. 2020 Jan 1;37(1):295-299
pubmed: 31504749
Nature. 2020 Aug;584(7820):257-261
pubmed: 32512579
Nat Protoc. 2017 Jun;12(6):1261-1276
pubmed: 28538739
Nature. 2021 Jul;595(7869):707-712
pubmed: 34098568
Virus Evol. 2021 Jul 30;7(2):veab064
pubmed: 34527285
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Int J Infect Dis. 2021 Mar;104:139-149
pubmed: 33359061
Heliyon. 2021 Jan;7(1):e06035
pubmed: 33495741
PLoS Genet. 2012;8(7):e1002764
pubmed: 22807683
Cell. 2021 May 13;184(10):2587-2594.e7
pubmed: 33861950
Sci Rep. 2020 Oct 20;10(1):17720
pubmed: 33082405
Science. 2021 Aug 20;373(6557):889-895
pubmed: 34301854
Lancet Glob Health. 2020 Jul;8(7):e886-e887
pubmed: 32416767
Nat Methods. 2017 Jun;14(6):587-589
pubmed: 28481363
Genome Biol. 2019 Jan 8;20(1):8
pubmed: 30621750