Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia.

Animals Cell Differentiation Humans Hypoxia / pathology Infant Infant, Newborn Mice Oligodendroglia / cytology Sirtuin 1 / genetics Sirtuin 2 / genetics White Matter / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
15 08 2022
Historique:
received: 04 10 2021
accepted: 01 08 2022
entrez: 15 8 2022
pubmed: 16 8 2022
medline: 18 8 2022
Statut: epublish

Résumé

Delayed oligodendrocyte (OL) maturation caused by hypoxia (Hx)-induced neonatal brain injury results in hypomyelination and leads to neurological disabilities. Previously, we characterized Sirt1 as a crucial regulator of OL progenitor cell (OPC) proliferation in response to Hx. We now identify Sirt2 as a critical promoter of OL differentiation during both normal white matter development and in a mouse model of Hx. Importantly, we find that Hx reduces Sirt2 expression in mature OLs and that Sirt2 overexpression in OPCs restores mature OL populations. Reduced numbers of Sirt2

Identifiants

DOI: 10.1038/s41467-022-32462-2 PMID: 35970992 PMC: PMC9378658
pubmed: 35970992
doi: 10.1038/s41467-022-32462-2
pii: 10.1038/s41467-022-32462-2
pmc: PMC9378658
doi:

Substances chimiques

SIRT2 protein, human EC 3.5.1.-
Sirtuin 1 EC 3.5.1.-
Sirtuin 2 EC 3.5.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4771

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD105328
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105138
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS109478
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090257
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Beata Jablonska (B)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA. bjablonska@childrensnational.org.

Katrina L Adams (KL)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA.
ORCID: 0000-0001-5290-4245

Panagiotis Kratimenos (P)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA.
Neonatology Department, Children's National Hospital, Washington, DC, 20010, USA.

Zhen Li (Z)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA.

Emma Strickland (E)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA.

Tarik F Haydar (TF)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA.

Katharina Kusch (K)

Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Gottingen, Germany.
ORCID: 0000-0002-5079-502X

Klaus-Armin Nave (KA)

Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Gottingen, Germany.
ORCID: 0000-0001-8724-9666

Vittorio Gallo (V)

Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, DC, 20010, USA. vgallo@childrensnational.org.
ORCID: 0000-0002-2429-0845

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-1 › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-2 › Sirt2 promotes white matter oligodendrogenesis...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Sirt2 promotes white matter oligodendrogenesis...