Impaired activation of transposable elements in SARS-CoV-2 infection.
COVID-19
SARS-CoV-2
epigenetics
interferon response
transposable elements
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 09 2022
05 09 2022
Historique:
revised:
26
07
2022
received:
23
03
2022
accepted:
27
07
2022
pubmed:
17
8
2022
medline:
9
9
2022
entrez:
16
8
2022
Statut:
ppublish
Résumé
Emerging evidence shows that transposable elements (TEs) are induced in response to viral infections. This TE induction is suggested to trigger a robust and durable interferon response, providing a host defense mechanism. Here, we analyze TE expression changes in response to SARS-CoV-2 infection in different human cellular models. Unlike other viruses, SARS-CoV-2 infection does not lead to global upregulation of TEs in primary cells. We report a correlation between TEs activation and induction of interferon-related genes, suggesting that failure to activate TEs may account for the weak interferon response. Moreover, we identify two variables that explain most of the observed diverseness in immune responses: basal expression levels of TEs in the pre-infected cells and the viral load. Finally, analyzing the SARS-CoV-2 interactome and the epigenetic landscape around the TEs activated following infection, we identify SARS-CoV-2 interacting proteins, which may regulate chromatin structure and TE transcription. This work provides a possible functional explanation for SARS-CoV-2 success in its fight against the host immune system and suggests that TEs could serve as potential drug targets for COVID-19.
Identifiants
pubmed: 35972201
doi: 10.15252/embr.202255101
pmc: PMC9442302
doi:
Substances chimiques
Antiviral Agents
0
DNA Transposable Elements
0
Interferons
9008-11-1
Banques de données
GEO
['GSE133329', 'GSE147507', 'GSE153277', 'GSE153970']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e55101Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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