Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
14
07
2020
accepted:
13
07
2022
revised:
11
07
2022
pubmed:
17
8
2022
medline:
15
12
2022
entrez:
16
8
2022
Statut:
ppublish
Résumé
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Identifiants
pubmed: 35974141
doi: 10.1038/s41380-022-01710-8
pii: 10.1038/s41380-022-01710-8
pmc: PMC9734053
mid: NIHMS1840537
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4419-4431Subventions
Organisme : NIA NIH HHS
ID : RC4 AG039029
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103612
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059421
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL086694
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004729
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015933
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL054457
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019771
Pays : United States
Organisme : NIA NIH HHS
ID : N01AG12100
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004446
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025005
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG009740
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG054936
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061356
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087660
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200800007C
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS087541
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA001455
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087652
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004402
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004424
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049607
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL054464
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093029
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119443
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122658
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032098
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033193
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200036C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036042
Pays : United States
Organisme : NIAAA NIH HHS
ID : K02 AA018755
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG048806
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65226
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182913
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066546
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA047988
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012502
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG020098
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG049050
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85083
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM012535
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL054481
Pays : United States
Organisme : NINDS NIH HHS
ID : UH2 NS100605
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92019D00031
Pays : United States
Organisme : NIA NIH HHS
ID : RC2 AG036495
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA015416
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072976
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85079
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087641
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG049505
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Science. 2018 Jun 22;360(6395):
pubmed: 29930110
Nat Neurosci. 2013 Sep;16(9):1228-1237
pubmed: 23912948
Eur J Neurosci. 2012 Dec;36(11):3559-67
pubmed: 22909094
Curr Top Dev Biol. 2015;112:415-65
pubmed: 25733148
Nat Commun. 2018 Feb 26;9(1):838
pubmed: 29483533
Mol Psychiatry. 2015 Oct;20(10):1197-204
pubmed: 25385369
Nat Protoc. 2014 May;9(5):1192-212
pubmed: 24762786
Mol Psychiatry. 2016 Nov;21(11):1624-1632
pubmed: 26809841
Lancet Neurol. 2012 Nov;11(11):1006-12
pubmed: 23079557
Int J Epidemiol. 2016 Jan 28;45(2):433-440
pubmed: 26822939
Nat Commun. 2018 May 8;9(1):1825
pubmed: 29739930
Nat Neurosci. 2004 Jun;7(6):664-72
pubmed: 15156146
Science. 2006 Oct 20;314(5798):475-8
pubmed: 17053149
Neuroscientist. 2006 Aug;12(4):285-90
pubmed: 16840704
Nat Neurosci. 2014 Oct;17(10):1418-1428
pubmed: 25174004
Psychol Bull. 2017 Sep;143(9):992-1009
pubmed: 28530428
Transl Psychiatry. 2017 Jan 17;7(1):e1006
pubmed: 28094815
Cereb Cortex. 1999 Jan-Feb;9(1):20-6
pubmed: 10022492
Psychol Med. 2016 Apr;46(6):1135-50
pubmed: 26690829
Brain. 1999 Oct;122 ( Pt 10):1963-71
pubmed: 10506097
Eur Arch Psychiatry Clin Neurosci. 2008 Sep;258(6):363-72
pubmed: 18437279
Nat Rev Neurosci. 2007 Jan;8(1):11-20
pubmed: 17133224
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Nat Commun. 2018 May 29;9(1):2098
pubmed: 29844566
PLoS One. 2016 Apr 25;11(4):e0154222
pubmed: 27110937
Biol Psychiatry. 2015 Apr 15;77(8):749-63
pubmed: 25648963
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2009 May;16(3):357-76
pubmed: 19353345
Cereb Cortex. 2019 Mar 1;29(3):1162-1173
pubmed: 29415163
PLoS Genet. 2017 Apr 7;13(4):e1006711
pubmed: 28388634
Mol Psychiatry. 2011 Feb;16(2):184-92
pubmed: 20038948
Neuroimage. 2010 Aug 1;52(1):379-88
pubmed: 20350608
Curr Opin Cell Biol. 2008 Oct;20(5):567-75
pubmed: 18602471
Bioinformatics. 2014 Apr 15;30(8):1185-1186
pubmed: 24395754
J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):90-97
pubmed: 30315123
Hum Mol Genet. 2007 Jun 15;16(12):1469-77
pubmed: 17470457
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Genes Brain Behav. 2011 Nov;10(8):844-51
pubmed: 21815997
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
PLoS Genet. 2011 Jan 13;7(1):e1001273
pubmed: 21249183
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5582-5587
pubmed: 29735686
Psychol Med. 2013 Jul;43(7):1543-54
pubmed: 23021014
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Nature. 2017 Oct 11;550(7675):204-213
pubmed: 29022597
Trends Cogn Sci. 2012 May;16(5):292-305
pubmed: 22542563
Genome Res. 2012 Sep;22(9):1790-7
pubmed: 22955989
Brain. 2018 Apr 1;141(4):1218-1228
pubmed: 29415119
Nat Commun. 2017 Nov 28;8(1):1826
pubmed: 29184056
Nat Genet. 2019 Nov;51(11):1624-1636
pubmed: 31636452
Neuropsychologia. 2006;44(10):1737-51
pubmed: 16635498
Nat Commun. 2017 Jan 18;8:13624
pubmed: 28098162
Mol Psychiatry. 2016 Jun;21(6):758-67
pubmed: 27046643
J Neurosci. 2010 Jul 28;30(30):9984-9
pubmed: 20668183
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Cell Rep. 2016 Nov 15;17(8):2042-2059
pubmed: 27851967
J Psychiatr Res. 2012 Feb;46(2):271-8
pubmed: 22126837
Nat Methods. 2012 Feb 28;9(3):215-6
pubmed: 22373907
BMC Med Genet. 2007 Sep 19;8 Suppl 1:S15
pubmed: 17903297
Nat Genet. 2018 Aug;50(8):1112-1121
pubmed: 30038396
Bioinformatics. 2017 Jan 15;33(2):272-279
pubmed: 27663502
Nat Genet. 2014 Mar;46(3):310-5
pubmed: 24487276
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
J Biol Chem. 1997 Feb 21;272(8):5236-40
pubmed: 9030594
Am J Psychiatry. 2003 May;160(5):911-8
pubmed: 12727695
Neuron. 2006 Jul 20;51(2):263-74
pubmed: 16846860
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
Hum Genet. 2016 Dec;135(12):1329-1341
pubmed: 27535846
Curr Opin Cell Biol. 1999 Oct;11(5):549-53
pubmed: 10508654
Nat Neurosci. 2016 Dec;19(12):1569-1582
pubmed: 27694991
Arch Gen Psychiatry. 2006 Feb;63(2):168-74
pubmed: 16461860
Brain Imaging Behav. 2021 Feb;15(1):288-299
pubmed: 32124274
Mol Psychiatry. 2013 Feb;18(2):255-63
pubmed: 22105620
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
PLoS One. 2017 Aug 11;12(8):e0182448
pubmed: 28800603
Hum Mol Genet. 2009 Dec 1;18(23):4650-61
pubmed: 19734545
Neuron. 2000 Oct;28(1):245-59
pubmed: 11086998
Hum Brain Mapp. 2018 Nov;39(11):4183-4195
pubmed: 29947131
Neuropsychology. 2011 Jul;25(4):488-98
pubmed: 21463045