Children who sleep more may have longer telomeres: evidence from a longitudinal population study in Spain.

Humans Child Child, Preschool Cohort Studies Spain Cross-Sectional Studies Sleep Telomere

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
04 2023
Historique:
received: 15 04 2022
accepted: 18 07 2022
revised: 13 07 2022
medline: 28 4 2023
pubmed: 17 8 2022
entrez: 16 8 2022
Statut: ppublish

Résumé

Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data. A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day). Leucocyte TL at 4 and 7-9 years were measured using quantitative PCR methods. Multiple robust linear regression models, through log-level regression models, were used to report the % of difference among tertiles of sleep duration. In comparison to children who slept between >10 and 11 h/day, those in the highest category (more than 11 h/day) had 8.5% (95% CI: 3.56-13.6) longer telomeres at 4 years. Longitudinal analysis showed no significant association between sleep duration at 4 years and TL at 7-9 years. Children who slept more hours per day had longer TL at 4 years independently of a wide range of confounder factors. Environmental conditions, such as sleep duration, might have a major impact on TL during the first years of life. Telomere length was longer in children with longer sleep duration (>11 h/day) independently of a wide range of confounder factors at age 4 and remained consistent by sex. Sleep routines are encouraged to promote positive child development, like the number of hours of sleep duration. Considering the complex biology of telomere length, future studies still need to elucidate which biological pathways might explain the association between sleep duration and telomere length.

Sections du résumé

BACKGROUND
Inadequate sleep duration has been suggested as a chronic stressor associated with changes in telomere length (TL). This study aimed to explore the association between sleep duration and TL using the INMA birth cohort study data.
METHODS
A total of 1014 children were included in this study (cross-sectional: 686; longitudinal: 872). Sleep duration (h/day) was reported by caregivers at 4 years and classified into tertiles (7-10 h/day; >10-11 h/day; >11-14 h/day). Leucocyte TL at 4 and 7-9 years were measured using quantitative PCR methods. Multiple robust linear regression models, through log-level regression models, were used to report the % of difference among tertiles of sleep duration.
RESULTS
In comparison to children who slept between >10 and 11 h/day, those in the highest category (more than 11 h/day) had 8.5% (95% CI: 3.56-13.6) longer telomeres at 4 years. Longitudinal analysis showed no significant association between sleep duration at 4 years and TL at 7-9 years.
CONCLUSION
Children who slept more hours per day had longer TL at 4 years independently of a wide range of confounder factors. Environmental conditions, such as sleep duration, might have a major impact on TL during the first years of life.
IMPACT
Telomere length was longer in children with longer sleep duration (>11 h/day) independently of a wide range of confounder factors at age 4 and remained consistent by sex. Sleep routines are encouraged to promote positive child development, like the number of hours of sleep duration. Considering the complex biology of telomere length, future studies still need to elucidate which biological pathways might explain the association between sleep duration and telomere length.

Identifiants

DOI: 10.1038/s41390-022-02255-w PMID: 35974160
pubmed: 35974160
doi: 10.1038/s41390-022-02255-w
pii: 10.1038/s41390-022-02255-w
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1419-1424

Informations de copyright

© 2022. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

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Auteurs

Fanny Petermann-Rocha (F)

Faculty of Medicine, Universidad Diego Portales, Santiago, Chile.
Institute of Cardiovascular Medical Sciences and Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Desirée Valera-Gran (D)

Department of Surgery and Pathology, Miguel Hernandez University, 03550, Alicante, Spain. dvalera@umh.es.
Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernández University, 03550, Alicante, Spain. dvalera@umh.es.

Paula Fernández-Pires (P)

Department of Surgery and Pathology, Miguel Hernandez University, 03550, Alicante, Spain.

Dries S Martens (DS)

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

Jordi Júlvez (J)

Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus, Spain.

Cristina Rodríguez-Dehli (C)

Servicio de Pediatría, Hospital San Agustín, Heros Street, 4, 33410, Avilés, Asturias, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain.

Ainara Andiarena (A)

Health Research Institute BIODONOSTIA, Donostia-San Sebastian, Basque Country, Spain.
Faculty of Psychology, University of the Basque Country (UPV/EHU), San Sebastian, Basque Country, Spain.

Manuel Lozano (M)

Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain.
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.

Ana Fernández-Somoano (A)

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001, Oviedo, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Unidad de Epidemiología Molecular del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA)-Departamento de Medicina, Universidad de Oviedo, Julián Clavería Street, s/n 33006, Oviedo, Asturias, Spain.

Aitana Lertxundi (A)

Health Research Institute BIODONOSTIA, Donostia-San Sebastian, Basque Country, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Preventive Medicine and Public Health Department, University of Basque Country (UPV/EHU), Leioa, Basque Country, Spain.

Sabrina Llop (S)

Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Mònica Guxens (M)

Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
ISGlobal, Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

Tim S Nawrot (TS)

Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

Eva-María Navarrete-Muñoz (EM)

Department of Surgery and Pathology, Miguel Hernandez University, 03550, Alicante, Spain.
Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernández University, 03550, Alicante, Spain.
Department of Surgery and Pathology, Miguel Hernandez University, Alicante Institute for Health and Biomedical Research (ISABIAL), 03550, Alicante, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Children who sleep more may have longer...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Children who sleep more may have longer...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Children who sleep more may have longer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Children who sleep more may have longer...
questionsmedicales.fr › Régions géographiques › Europe › Espagne › Children who sleep more may have longer...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Children who sleep more may have longer...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Children who sleep more may have longer...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Children who sleep more may have longer...