Therapeutic Efficacy of Botulinum Toxin in Trigeminal Neuralgia.
botulinum injection
botulinum toxin-a
secondary trigeminal neuralgia
therapeutic interventions
trigeminal nerve
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
accepted:
14
07
2022
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
18
8
2022
Statut:
epublish
Résumé
Trigeminal neuralgia (TN) is a unilateral, paroxysmal, sharp, shooting, or jabbing pain that occurs in the trigeminal nerve divisions, including the ophthalmic (V1), maxillary (V2), and mandibular (V3) nerves. Typically, an episode is triggered by anything touching the face or teeth. TN is a clinical diagnosis with no specific diagnostic test; it is determined by the patient's medical history and pain description. Imaging is necessary to exclude secondary causes. The precise reason for TN is uncertain, but it is commonly believed to result from vascular compression of the trigeminal nerve root, typically near its origin in the pons. There are numerous surgical and medical treatment options available. The most frequently applied medical treatment therapies are carbamazepine and oxcarbazepine. Surgical alternatives are reserved for patients who do not respond to medical treatment. Botulinum toxin A (BTX-A) has emerged as a novel and promising alternative to surgery for individuals whose pain is unresponsive to medication. Multiple studies have established the safety and usefulness of BTX-A in treating TN, with the most significant benefits occurring between six weeks and three months after the surgery. This article reviews various studies published in the last 10 years regarding the therapeutic use of BTX-A in TN. These studies include various observational, clinical, pilot, and animal studies.
Identifiants
pubmed: 35974855
doi: 10.7759/cureus.26856
pmc: PMC9375637
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e26856Informations de copyright
Copyright © 2022, Kayani et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Pain Res. 2021 Nov 03;14:3437-3463
pubmed: 34764686
J Headache Pain. 2021 May 17;22(1):38
pubmed: 34000998
Medicine (Baltimore). 2017 Sep;96(39):e8133
pubmed: 28953646
Pharmacology. 2015;95(1-2):65-9
pubmed: 25613637
Pain Res Manag. 2018 Apr 5;2018:7365148
pubmed: 29849847
Toxins (Basel). 2015 Aug 14;7(8):3127-54
pubmed: 26287242
Neurosciences (Riyadh). 2015 Apr;20(2):107-14
pubmed: 25864062
J Neurosci Rural Pract. 2018 Jan-Mar;9(1):100-105
pubmed: 29456352
Semin Ophthalmol. 2019;34(4):198-204
pubmed: 31177893
Toxins (Basel). 2021 Oct 05;13(10):
pubmed: 34678997
J Headache Pain. 2014 Sep 27;15:65
pubmed: 25263254
Cochrane Database Syst Rev. 2011 Jan 19;(1):CD005451
pubmed: 21249671
J Toxicol. 2012;2012:648384
pubmed: 22745637
J Headache Pain. 2014 Jun 22;15:43
pubmed: 24952600
Indian J Dermatol. 2010;55(1):8-14
pubmed: 20418969
Cephalalgia. 2017 Jun;37(7):648-657
pubmed: 28076964
Mol Pain. 2020 Jan-Dec;16:1744806920901890
pubmed: 31908187
Curr Neuropharmacol. 2020;18(2):109-119
pubmed: 31608834
BMC Fam Pract. 2008 May 06;9:26
pubmed: 18460194
J Craniofac Surg. 2011 May;22(3):894-8
pubmed: 21558885
Pract Neurol. 2021 Oct;21(5):392-402
pubmed: 34108244
Brain. 2001 Dec;124(Pt 12):2347-60
pubmed: 11701590
Headache. 2019 Sep;59(8):1229-1239
pubmed: 31342515
J Headache Pain. 2017 Aug 10;18(1):81
pubmed: 28799056
J Oral Maxillofac Res. 2020 Jun 30;11(2):e2
pubmed: 32760475
Mov Disord Clin Pract. 2018 Mar 09;5(3):321-322
pubmed: 30363389
J Pain Res. 2018 Oct 12;11:2343-2351
pubmed: 30349359
BMJ. 2007 Jan 27;334(7586):201-5
pubmed: 17255614
Acta Neurochir (Wien). 2011 Aug;153(8):1601-9
pubmed: 21538196
CNS Drugs. 2013 Feb;27(2):91-6
pubmed: 23225488
Exp Ther Med. 2019 Nov;18(5):3375-3382
pubmed: 31602211
J Headache Pain. 2013 Nov 19;14:92
pubmed: 24251833
Br J Anaesth. 2019 Aug;123(2):e385-e396
pubmed: 31208761
Neurosurg Clin N Am. 1997 Jan;8(1):31-9
pubmed: 9018703
Pain. 2011 Mar;152(3):507-513
pubmed: 21239113
Toxins (Basel). 2017 Aug 24;9(9):
pubmed: 28837075
J Pain Res. 2019 Jul 17;12:2177-2186
pubmed: 31410051