Global systematic review and meta-analysis of health-related quality of life in Behcet's patients.
Behcet’s disease
HRQOL
Health-related quality of life
Old Silk Route disease
Journal
Caspian journal of internal medicine
ISSN: 2008-6164
Titre abrégé: Caspian J Intern Med
Pays: Iran
ID NLM: 101523876
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
06
2021
revised:
22
11
2021
accepted:
08
12
2021
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
18
8
2022
Statut:
ppublish
Résumé
Behcet's disease (BD) is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet's disease. A total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021. All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included. Totally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients' age, gender, disease duration and depression (pvalue: 0.00). As the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for Health-Related Quality of Life (HRQOL) among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies.
Sections du résumé
Background
UNASSIGNED
Behcet's disease (BD) is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet's disease.
Methods
UNASSIGNED
A total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021. All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included.
Results
UNASSIGNED
Totally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients' age, gender, disease duration and depression (pvalue: 0.00).
Conclusion
UNASSIGNED
As the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for Health-Related Quality of Life (HRQOL) among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies.
Identifiants
pubmed: 35974926
doi: 10.22088/cjim.13.3.447
pmc: PMC9348218
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
447-457Déclaration de conflit d'intérêts
The authors declare that they have no competing interests
Références
Neurol Sci. 2021 Mar;42(3):1081-1086
pubmed: 32743747
Mod Rheumatol. 2019 Nov;29(6):1023-1030
pubmed: 30557064
Afr Health Sci. 2010 Dec;10(4):374-85
pubmed: 21416040
Acta Reumatol Port. 2014 Jan-Mar;39(1):46-53
pubmed: 24811461
Niger J Clin Pract. 2020 May;23(5):680-685
pubmed: 32367876
Turk J Phys Med Rehabil. 2017 Jun 03;63(2):160-164
pubmed: 31453445
Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S107-12
pubmed: 26487169
Ann Med Surg (Lond). 2020 Apr 13;54:43-46
pubmed: 32368339
Mod Rheumatol. 2020 Mar;30(2):219-224
pubmed: 31747804
Int J Dermatol. 2003 May;42(5):346-51
pubmed: 12755969
Rheumatology (Oxford). 2010 Nov;49(11):2165-71
pubmed: 20675710
Korean J Intern Med. 2017 Mar;32(2):352-359
pubmed: 28192886
Int J Dermatol. 2007 Nov;46(11):1118-24
pubmed: 17988328
Front Neurol. 2018 Jan 11;8:729
pubmed: 29375468
Rheumatol Int. 2010 May;30(7):941-6
pubmed: 19657642
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Int J Psychiatry Clin Pract. 2007;11(1):16-20
pubmed: 24941271
Intern Emerg Med. 2017 Oct;12(7):947-955
pubmed: 28620840
Iran J Med Sci. 2020 Sep;45(5):352-358
pubmed: 33060878
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
J Oral Pathol Med. 2007 Mar;36(3):147-52
pubmed: 17305636
Clin Rheumatol. 2006 May;25(3):329-33
pubmed: 16267609
Int J Rheum Dis. 2018 Dec;21(12):2139-2145
pubmed: 26913703
J Affect Disord. 2021 Jan 1;278:33-45
pubmed: 32949871
Acta Reumatol Port. 2013 Oct-Dec;38(4):252-60
pubmed: 24435030
Can J Psychiatry. 2021 Mar;66(3):298-305
pubmed: 32783472
Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S18-22
pubmed: 19796527
Int J Rheum Dis. 2019 Jun;22(6):974-979
pubmed: 30398004
Arthritis Res Ther. 2013 Mar 21;15(2):R45
pubmed: 23517876
Jpn J Ophthalmol. 2003 Jan-Feb;47(1):85-92
pubmed: 12586184
Asian Nurs Res (Korean Soc Nurs Sci). 2011 Dec;5(4):229-35
pubmed: 25030525
BMJ Support Palliat Care. 2022 Jun;12(2):158-166
pubmed: 32963057
Eur Neurol. 2014;71(3-4):115-9
pubmed: 24457203