Iridoids as a Potential Hepatoprotective Class: A Review.
Antioxidants
anti-inflammatory
hepatotoxicity
iridoids
mechanisms
oxidative stress
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
04
2022
revised:
28
04
2022
accepted:
29
04
2022
pubmed:
18
8
2022
medline:
17
3
2023
entrez:
17
8
2022
Statut:
ppublish
Résumé
Liver disease rates are gradually increasing over the years, becoming a severe public health problem. The indiscriminate use of drugs associated with a rich fat diet, high consumption of alcoholic beverages, and exposure to viral infections and lipid peroxidative products are considered the chief factors for developing hepatic disorders. Owing to the absence of reliable hepatoprotective drugs in the therapeutic arsenal, since they present a high incidence of adverse reactions and/or lack of efficacy in some cases, liver diseases are widely treated with medicinal plants. Among them are the plants producing iridoids, which are believed to be good remedies for liver disease due to their bitter taste. The hepatoprotective effect of iridoids and extracts, rich in these compounds, has been demonstrated, both in vitro and in vivo. This review aims to scrutinize the available literature related to the hepatoprotective activity of iridoids. The information was obtained from scientific databases (Science Direct, PubMed, Web of Science, Scopus, ACS Publications, Wiley Online Library) until December, 2021. A total of 63 hepatoprotective iridoids were found, including aucubin, catalpol and picroliv, a mixture of two iridoids. They are the target of a high number of studies, which revealed their protective action against different hepatotoxic agents and detailed action mechanisms.
Sections du résumé
BACKGROUND
BACKGROUND
Liver disease rates are gradually increasing over the years, becoming a severe public health problem. The indiscriminate use of drugs associated with a rich fat diet, high consumption of alcoholic beverages, and exposure to viral infections and lipid peroxidative products are considered the chief factors for developing hepatic disorders. Owing to the absence of reliable hepatoprotective drugs in the therapeutic arsenal, since they present a high incidence of adverse reactions and/or lack of efficacy in some cases, liver diseases are widely treated with medicinal plants. Among them are the plants producing iridoids, which are believed to be good remedies for liver disease due to their bitter taste. The hepatoprotective effect of iridoids and extracts, rich in these compounds, has been demonstrated, both in vitro and in vivo.
OBJECTIVE
OBJECTIVE
This review aims to scrutinize the available literature related to the hepatoprotective activity of iridoids.
METHODS
METHODS
The information was obtained from scientific databases (Science Direct, PubMed, Web of Science, Scopus, ACS Publications, Wiley Online Library) until December, 2021.
RESULTS AND CONCLUSION
CONCLUSIONS
A total of 63 hepatoprotective iridoids were found, including aucubin, catalpol and picroliv, a mixture of two iridoids. They are the target of a high number of studies, which revealed their protective action against different hepatotoxic agents and detailed action mechanisms.
Identifiants
pubmed: 35975865
pii: MRMC-EPUB-125499
doi: 10.2174/1389557522666220816130158
doi:
Substances chimiques
Iridoids
0
Plant Extracts
0
Antioxidants
0
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
452-479Subventions
Organisme : FAPERGS
ID : Edital PG 02/2017- Processo 17/1025-6
Organisme : CAPES and CNPq
ID : Edital 01/2016 - Processo 406282/2016-1, PQ- Processo 307096/2017-3
Organisme : Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago
ID : 8380000
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.