Effects of the LC mobile phase in vacuum differential mobility spectrometry-mass spectrometry for the selective analysis of antidepressant drugs in human plasma.
Antidepressants
Differential mobility spectrometry
FAIMS
Isobaric drugs
Plasma
Quantification
Trap-elute LC
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
22
05
2022
accepted:
09
08
2022
revised:
28
07
2022
pubmed:
18
8
2022
medline:
21
9
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
The effect of LC mobile phase composition and flow rate (2-50 µL/min) on mobility behavior in vacuum differential mobility spectrometry (vDMS) was investigated for electrosprayed isobaric antidepressant drugs (AD); amitriptyline, maprotiline, venlafaxine; and structurally related antidepressants nortriptyline, imipramine, and desipramine. While at 2 µL/min, no difference in compensation voltage was observed with methanol and acetonitrile, at 50 µL/min, acetonitrile used for LC elution of analytes enabled the selectivity of the mobility separation to be improved. An accurate and sensitive method could be developed for the quantification of six AD drugs in human plasma using trap/elute micro-LC setup hyphenated to vDMS with mass spectrometric detection in the selected ion monitoring mode. The assay was found to be linear over three orders of magnitude, and the limit of quantification was of 25 ng/mL for all analytes. The LC-vDMS-SIM/MS method was compared to a LC-MRM/MS method, and in both cases, inter-assay precisions were lower than 12.5 and accuracies were in the range 91.5-110%, but with a four times reduced analysis time (2 min) for the LC-vDMS-SIM/MS method. This work illustrates that with vDMS, the LC mobile phase composition can be used to tune the ion mobility separation and to improve assay selectivity without additional hardware.
Identifiants
pubmed: 35976423
doi: 10.1007/s00216-022-04276-0
pii: 10.1007/s00216-022-04276-0
pmc: PMC9482904
doi:
Substances chimiques
Acetonitriles
0
Antidepressive Agents
0
Amitriptyline
1806D8D52K
Maprotiline
2U1W68TROF
Venlafaxine Hydrochloride
7D7RX5A8MO
Nortriptyline
BL03SY4LXB
Imipramine
OGG85SX4E4
Desipramine
TG537D343B
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7243-7252Informations de copyright
© 2022. The Author(s).
Références
Schütze G, Schwarz MJ. Therapeutic drug monitoring for individualised risk reduction in psychopharmacotherapy. TrAC Trends Anal Chem. 2016;84:14–22. https://doi.org/10.1016/j.trac.2016.05.027 .
doi: 10.1016/j.trac.2016.05.027
Uddin MN, Samanidou VF, Papadoyannis IN. Bio-sample preparation and analytical methods for the determination of tricyclic antidepressants. Bioanalysis. 2011;3(1):97–118. https://doi.org/10.4155/bio.10.160 .
doi: 10.4155/bio.10.160
pubmed: 21175370
Manousi N, Samanidou VF. Applications of gas chromatography for the analysis of tricyclic antidepressants in biological matrices. Separations. 2019;6(2):24. https://doi.org/10.3390/separations6020024 .
doi: 10.3390/separations6020024
Esteve-Romero J, Albiol-Chiva J, Peris-Vicente J. A review on development of analytical methods to determine monitorable drugs in serum and urine by micellar liquid chromatography using direct injection. Anal Chim Acta. 2016;926:1–16. https://doi.org/10.1016/j.aca.2016.04.026 .
doi: 10.1016/j.aca.2016.04.026
pubmed: 27216388
Manousi N, Samanidou VF. Recent advances in the HPLC analysis of tricyclic antidepressants in bio-samples. Mini-Rev Med Chem. 2020;20(1):24–38. https://doi.org/10.2174/1389557519666190617150518 .
doi: 10.2174/1389557519666190617150518
pubmed: 31288718
Kirk AT, Bohnhorst A, Raddatz CR, Allers M, Zimmermann S. Ultra-high-resolution ion mobility spectrometry-current instrumentation, limitations, and future developments. Anal Bioanal Chem. 2019;411(24):6229–46. https://doi.org/10.1007/s00216-019-01807-0 .
doi: 10.1007/s00216-019-01807-0
pubmed: 30957205
Cumeras R, Figueras E, Davis CE, Baumbach JI, Gracia I. Review on ion mobility spectrometry. Part 1: current instrumentation. Analyst. 2015;140(5):1376–90. https://doi.org/10.1039/c4an01100g .
doi: 10.1039/c4an01100g
pubmed: 25465076
pmcid: 4331213
Paglia G, Smith AJ, Astarita G. Ion mobility mass spectrometry in the omics era: challenges and opportunities for metabolomics and lipidomics. Mass Spec Rev. 2021. https://doi.org/10.1002/mas.21686 .
doi: 10.1002/mas.21686
Jafari MT, Saraji M, Sherafatmand H. Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Anal Bioanal Chem. 2011;399(10):3555–64. https://doi.org/10.1007/s00216-011-4730-z .
doi: 10.1007/s00216-011-4730-z
pubmed: 21298415
Roscioli KM, Tufariello JA, Zhang X, Li SX, Goetz GH, Cheng G, et al. Desorption electrospray ionization (DESI) with atmospheric pressure ion mobility spectrometry for drug detection. Analyst. 2014;139(7):1740–50. https://doi.org/10.1039/C3AN02113K .
doi: 10.1039/C3AN02113K
pubmed: 24551872
Aladaghlo Z, Fakhari AR, Hasheminasab KS. Application of electromembrane extraction followed by corona discharge ion mobility spectrometry analysis as a fast and sensitive technique for determination of tricyclic antidepressants in urine samples. Microchem J. 2016;129:41–8. https://doi.org/10.1016/j.microc.2016.05.013 .
doi: 10.1016/j.microc.2016.05.013
Barati E, Alizadeh N. Simultaneous determination of sertraline, imipramine and alprazolam in human plasma samples using headspace solid phase microextraction based on a nanostructured polypyrrole fiber coupled to ion mobility spectrometry. Anal Methods. 2020;12(7):930–7. https://doi.org/10.1039/C9AY02001B .
doi: 10.1039/C9AY02001B
Zamani F, Farajmand B, Yaftian MR. Corona discharge ion mobility spectrometry combined by homogenizer assisted dispersive liquid-phase microextraction; a rapid and sensitive method for quantification of nortriptyline. Microchem J. 2020;159: 105540. https://doi.org/10.1016/j.microc.2020.105540 .
doi: 10.1016/j.microc.2020.105540
Piendl SK, Raddatz C-R, Hartner NT, Thoben C, Warias R, Zimmermann S, et al. 2D in seconds: coupling of chip-HPLC with ion mobility spectrometry. Anal Chem. 2019;91(12):7613–20. https://doi.org/10.1021/acs.analchem.9b00302 .
doi: 10.1021/acs.analchem.9b00302
pubmed: 31082255
Schneider B, Nazarov E, Londry F, Vouros P, Covey T. Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications: differential mobility spectrometry/mass spectrometry. Mass Spec Rev. 2015;35. https://doi.org/10.1002/mas.21453 .
Ruskic D, Hopfgartner G. Modifier selectivity effect on differential ion mobility resolution of isomeric drugs and multidimensional liquid chromatography ion mobility analysis. Anal Chem. 2019;91(18):11670–7. https://doi.org/10.1021/acs.analchem.9b02212 .
doi: 10.1021/acs.analchem.9b02212
pubmed: 31429276
Werres T, Leonhardt J, Jager M, Teutenberg T. Critical comparison of liquid chromatography coupled to mass spectrometry and three different ion mobility spectrometry systems on their separation capability for small isomeric compounds (vol 82, pg 251, 2019). Chromatographia. 2019;82(9):1427. https://doi.org/10.1007/s10337-019-03756-3 .
doi: 10.1007/s10337-019-03756-3
Lam KHB, Le Blanc JCY, Campbell JL. Separating isomers, conformers, and analogues of cyclosporin using differential mobility spectroscopy, mass spectrometry, and hydrogen-deuterium exchange. Anal Chem. 2020;92(16):11053–61. https://doi.org/10.1021/acs.analchem.0c00191 .
doi: 10.1021/acs.analchem.0c00191
pubmed: 32698568
Bravo-Veyrat S, Hopfgartner G. High-throughput liquid chromatography differential mobility spectrometry mass spectrometry for bioanalysis: determination of reduced and oxidized form of glutathione in human blood. Anal Bioanal Chem. 2018;410(27):7153–61. https://doi.org/10.1007/s00216-018-1318-x .
doi: 10.1007/s00216-018-1318-x
pubmed: 30151684
Chen Z, Coy S, Pannkuk EL, Laiakis EC, Fornace AJ, Vouros P. Differential mobility spectrometry-mass spectrometry (DMS-MS) in radiation biodosimetry: rapid and high-throughput quantitation of multiple radiation biomarkers in nonhuman primate urine. J Am Soc Mass Spectr. 2018;29(8):1650–64. https://doi.org/10.1007/s13361-018-1977-z .
doi: 10.1007/s13361-018-1977-z
Liu C, Gomez-Rios GA, Schneider BB, Le Blanc JCY, Reyes-Garces N, Arnold DW, et al. Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface. Anal Chim Acta. 2017;991:89–94. https://doi.org/10.1016/j.aca.2017.08.023 .
doi: 10.1016/j.aca.2017.08.023
pubmed: 29031302
Shvartsburg AA, Haris A, Andrzejewski R, Entwistle A, Giles R. Differential ion mobility separations in the low-pressure regime. Anal Chem. 2018;90(1):936–43. https://doi.org/10.1021/acs.analchem.7b03925 .
doi: 10.1021/acs.analchem.7b03925
pubmed: 29179535
Andrzejewski R, Entwistle A, Giles R, Shvartsburg AA. Ion mobility spectrometry of superheated macromolecules at electric fields up to 500 Td. Anal Chem. 2021;93(35):12049–58. https://doi.org/10.1021/acs.analchem.1c02299 .
doi: 10.1021/acs.analchem.1c02299
pubmed: 34423987
Kirchherr H, Kühn-Velten WN. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. J Chromatrogr B. 2006;843(1):100–13. https://doi.org/10.1016/j.jchromb.2006.05.031 .
doi: 10.1016/j.jchromb.2006.05.031
Ruskic D, Klont F, Hopfgartner G. Clustering and nonclustering modifier mixtures in differential mobility spectrometry for multidimensional liquid chromatography ion mobility-mass spectrometry analysis. Anal Chem. 2021;93(17):6638–45. https://doi.org/10.1021/acs.analchem.0c04889 .
doi: 10.1021/acs.analchem.0c04889
pubmed: 33891812