Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity.
BMP signaling
HSF-1
Rab GTPases
SMAD
TGF-β
aging
endocytosis
gut-neuron axis
membrane traffic
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
24
06
2022
received:
28
01
2022
accepted:
27
07
2022
pubmed:
18
8
2022
medline:
16
9
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
Aging is a complex and highly regulated process of interwoven signaling mechanisms. As an ancient transcriptional regulator of thermal adaptation and protein homeostasis, the Heat Shock Factor, HSF-1, has evolved functions within the nervous system to control age progression; however, the molecular details and signaling dynamics by which HSF-1 modulates age across tissues remain unclear. Herein, we report a nonautonomous mode of age regulation by HSF-1 in the Caenorhabditis elegans nervous system that works through the bone morphogenic protein, BMP, signaling pathway to modulate membrane trafficking in peripheral tissues. In particular, HSF-1 represses the expression of the neuron-specific BMP ligand, DBL-1, and initiates a complementary negative feedback loop within the intestine. By reducing receipt of DBL-1 in the periphery, the SMAD transcriptional coactivator, SMA-3, represses the expression of critical membrane trafficking regulators including Rab GTPases involved in early (RAB-5), late (RAB-7), and recycling (RAB-11.1) endosomal dynamics and the BMP receptor binding protein, SMA-10. This reduces cell surface residency and steady-state levels of the type I BMP receptor, SMA-6, in the intestine and further dampens signal transmission to the periphery. Thus, the ability of HSF-1 to coordinate BMP signaling along the gut-brain axis is an important determinate in age progression.
Identifiants
pubmed: 35977034
doi: 10.1111/acel.13693
pmc: PMC9470895
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Transcription Factors
0
sma-3 protein, C elegans
0
Bone Morphogenetic Protein Receptors
EC 2.7.11.30
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13693Subventions
Organisme : NIA NIH HHS
ID : R01 AG076529
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061338
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097591
Pays : United States
Informations de copyright
© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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