Transfusion Strategies for Hemostatic Blood Products in Critically Ill Children: A Narrative Review and Update on Expert Consensus Guidelines.


Journal

Anesthesia and analgesia
ISSN: 1526-7598
Titre abrégé: Anesth Analg
Pays: United States
ID NLM: 1310650

Informations de publication

Date de publication:
01 09 2022
Historique:
entrez: 17 8 2022
pubmed: 18 8 2022
medline: 20 8 2022
Statut: ppublish

Résumé

Critically ill children commonly receive coagulant products (plasma and/or platelet transfusions) to prevent or treat hemorrhage or correct coagulopathy. Unique aspects of pediatric developmental physiology, and the complex pathophysiology of critical illness must be considered and balanced against known transfusion risks. Transfusion practices vary greatly within and across institutions, and high-quality evidence is needed to support transfusion decision-making. We present recent recommendations and expert consensus statements to direct clinicians in the decision to transfuse or not to transfuse hemostatic blood products, including plasma, platelets, cryoprecipitate, and recombinant products to critically ill children.

Identifiants

pubmed: 35977364
doi: 10.1213/ANE.0000000000006149
pii: 00000539-202209000-00013
doi:

Substances chimiques

Hemostatics 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

545-557

Informations de copyright

Copyright © 2022 International Anesthesia Research Society.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Références

Goel R, Josephson CD, Patel EU, et al. Individual- and hospital-level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion. 2020;60:1700–1712.
Nellis ME, Goel R, Hendrickson JE, ; NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P). Transfusion practices in a large cohort of hospitalized children. Transfusion. 2021;61:2042–2053.
Karam O, Demaret P, Shefler A, ; Canadian Critical Care Trials Group (CCCTG); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI); BloodNet; PlasmaTV Investigators. Indications and effects of plasma transfusions in critically ill children. Am J Respir Crit Care Med. 2015;191:1395–1402.
Nellis ME, Karam O, Mauer E, ; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network, Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators. Platelet transfusion practices in critically ill children. Crit Care Med. 2018;46:1309–1317.
Nellis ME, Karam O, Valentine SL, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Executive summary of recommendations and expert consensus for plasma and platelet transfusion practice in critically ill children: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022;23:34–51.
Kleinman S, Chan P, Robillard P. Risks associated with transfusion of cellular blood components in Canada. Transfus Med Rev. 2003;17:120–162.
Murphy EL, Kwaan N, Looney MR, ; TRALI Study Group. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013;126:357.e29–357.e38.
Toy P, Gajic O, Bacchetti P, ; TRALI Study Group. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119:1757–1767.
Muszynski JA, Spinella PC, Cholette JM, ; Pediatric Critical Care Blood Research Network (Blood Net). Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness. Transfusion. 2017;57:195–206.
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sang. 2013;104:342–349.
Kaufman RM, Djulbegovic B, Gernsheimer T, ; AABB. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2015;162:205–213.
New HV, Berryman J, Bolton-Maggs PH, ; British Committee for Standards in Haematology. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. 2016;175:784–828.
New HV, Stanworth SJ, Gottstein R, et al. British Society for Haematology Guidelines on transfusion for fetuses, neonates and older children (Br J Haematol. 2016;175:784-828). Br J Haematol. 2020;191:725–727.
Green L, Bolton-Maggs P, Beattie C, et al. British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding. Br J Haematol. 2018;181:54–67.
O’Shaughnessy DF, Atterbury C, Bolton Maggs P, ; British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol. 2004;126:11–28.
Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G; Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Work Group. Recommendations for the transfusion of plasma and platelets. Blood Transfus. 2009;7:132–150.
Commonwealth of Australia. The National Blood Authority (NBA)Australia. Patient Blood Management Guidelines: module 6 neontal and paediatrics. 2016. Accessed April 1, 2022. https://www.blood.gov.au/system/files/14523_NBA-Module-6-Neonat_Paediatrics_internals_5_updated_14_May_2020.pdf .
Ward G. Transfusion of plasma. Br Med J. 1918;1:301.
Stetten D. The blood plasma for great Britain project. Bull N Y Acad Med. 1941;17:27–38.
Schmidt PJ. The plasma wars: a history. Transfusion. 2012;52(suppl 1):2S–4S.
Watson JJ, Pati S, Schreiber MA. Plasma transfusion: history, current realities, and novel improvements. Shock. 2016;46:468–479.
Duke WW. The relation of blood platelets to hemorrhagic disease. By W.W. Duke. JAMA. 1983;250:1201–1209.
Gaydos LA, Freireich EJ, Mantel N. The quantitative relation between platelet count and hemorrhage in patients with acute leukemia. N Engl J Med. 1962;266:905–909.
Freireich EJ. Origins of platelet transfusion therapy. Transfus Med Rev. 2011;25:252–256.
Levin RH, Pert JH, Freireich EJ. Response to transfusion of platelets pooled from multiple donors and the effects of various technics of concentrating platelets. Transfusion. 1965;5:54–63.
Murphy S, Sayar SN, Gardner FH. Storage of platelet concentrates at 22°C. Blood. 1970;35(4):549–557. Blood. 2016;128:1155.
Serious Hazards of Transfusion (SHOT). Shotuk.org. 2020. Accessed May 1, 2021. https://www.shotuk.org/wp-content/uploads/myimages/shot-report-2020.pdf .
Vossoughi S, Perez G, Whitaker BI, Fung MK, Stotler B. Analysis of pediatric adverse reactions to transfusions. Transfusion. 2018;58:60–69.
Curley A, Stanworth SJ, Willoughby K, et al.; PlaNeT2 MATISSE Collaborators. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med. 2019;380:242–251.
Andrew M, Paes B, Milner R, et al. Development of the human coagulation system in the full-term infant. Blood. 1987;70:165–172.
Andrew M, Paes B, Milner R, et al. Development of the human coagulation system in the healthy premature infant. Blood. 1988;72:1651–1657.
Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L. Maturation of the hemostatic system during childhood. Blood. 1992;80:1998–2005.
Reverdiau-Moalic P, Delahousse B, Body G, Bardos P, Leroy J, Gruel Y. Evolution of blood coagulation activators and inhibitors in the healthy human fetus. Blood. 1996;88:900–906.
Strauss T, Sidlik-Muskatel R, Kenet G. Developmental hemostasis: primary hemostasis and evaluation of platelet function in neonates. Semin Fetal Neonatal Med. 2011;16:301–304.
Roschitz B, Sudi K, Köstenberger M, Muntean W. Shorter PFA-100 closure times in neonates than in adults: role of red cells, white cells, platelets and von Willebrand factor. Acta Paediatr. 2001;90:664–670.
Bednarek FJ, Bean S, Barnard MR, Frelinger AL, Michelson AD. The platelet hyporeactivity of extremely low birth weight neonates is age-dependent. Thromb Res. 2009;124:42–45.
Klarmann D, Eggert C, Geisen C, et al. Association of ABO(H) and I blood group system development with von Willebrand factor and Factor VIII plasma levels in children and adolescents. Transfusion. 2010;50:1571–1580.
Josephson CD, Granger S, Assmann SF, et al. Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. Blood. 2012;120:748–760.
Delaney M, Karam O, Lieberman L, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. What laboratory tests and physiologic triggers should guide the decision to administer a platelet or plasma transfusion in critically ill children and what product attributes are optimal to guide specific product selection? From the transfusion and anemia expertise initiative-control/avoidance of bleeding. Pediatr Crit Care Med. 2022;23:e1–e13.
Russell R, Bauer DF, Goobie SM, ; Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Plasma and platelet transfusion strategies in critically ill children following severe trauma, traumatic brain injury, and/or intracranial hemorrhage: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022;23:e14–e24.
Cholette JM, Muszynski JA, Ibla JC, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Plasma and platelet transfusions strategies in neonates and children undergoing cardiac surgery with cardiopulmonary bypass or neonates and children supported by extracorporeal membrane oxygenation: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022;23:e25–e36.
Lieberman L, Karam O, Stanworth SJ, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Plasma and platelet transfusion strategies in critically ill children with malignancy, acute liver failure and/or liver transplantation, or sepsis: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022;23:e37–e49.
Tucci M, Crighton G, Goobie SM, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Plasma and platelet transfusion strategies in critically ill children following noncardiac surgery and critically ill children undergoing invasive procedures outside the operating room: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022;23:e50–e62.
Nellis ME, Remy KE, Lacroix J, ; Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Research priorities for plasma and platelet transfusion strategies in critically ill children: from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022;23:e63–e73.
Neff LP, Cannon JW, Morrison JJ, Edwards MJ, Spinella PC, Borgman MA. Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat data. J Trauma Acute Care Surg. 2015;78:22–28.
Leonard JC, Josephson CD, Luther JF, et al. Life-threatening bleeding in children: a prospective observational study. Crit Care Med. 2021;49:1943–1954.
Meyer DE, Vincent LE, Fox EE, et al. Every minute counts: time to delivery of initial massive transfusion cooler and its impact on mortality. J Trauma Acute Care Surg. 2017;83:19–24.
Phillips R, Shahi N, Acker SN, et al. Not as simple as ABC: tools to trigger massive transfusion in pediatric trauma. J Trauma Acute Care Surg. 2022;92:422–427.
Holcomb JB, Tilley BC, Baraniuk S, et al.; PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313:471–482.
Butler EK, Mills BM, Arbabi S, et al. Association of blood component ratios with 24-hour mortality in injured children receiving massive transfusion. Crit Care Med. 2019;47:975–983.
Cunningham ME, Rosenfeld EH, Zhu H, Naik-Mathuria BJ, Russell RT, Vogel AM. A High ratio of plasma: RBC improves survival in massively transfused injured children. J Surg Res. 2019;233:213–220.
Nosanov L, Inaba K, Okoye O, et al. The impact of blood product ratios in massively transfused pediatric trauma patients. Am J Surg. 2013;206:655–660.
Williams J, Merutka N, Meyer D, et al. Safety profile and impact of low-titer group O whole blood for emergency use in trauma. J Trauma Acute Care Surg. 2020;88:87–93.
Shea SM, Staudt AM, Thomas KA, et al. The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage. Transfusion. 2020;60(suppl 3):S2–S9.
Morgan KM, Yazer MH, Triulzi DJ, Strotmeyer S, Gaines BA, Leeper CM. Safety profile of low-titer group O whole blood in pediatric patients with massive hemorrhage. Transfusion. 2021;61(suppl 1):S8–S14.
Valentine SL, Bembea MM, Muszynski JA, et al.; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Consensus recommendations for RBC transfusion practice in critically ill children from the pediatric critical care transfusion and anemia expertise initiative. Pediatr Crit Care Med. 2018;19:884–898.
Goobie SM, Gallagher T, Gross I, Shander A. Society for the advancement of blood management administrative and clinical standards for patient blood management programs. 4th edition (pediatric version). Paediatr Anaesth. 2019;29:231–236.
Goobie SM, Shander A. One size does not fit all in treating massive hemorrhage. Anesth Analg. 2020;131:480–482.
Haas T, Cushing MM. Hemostatic balance in severe trauma. Front Pediatr. 2020;8:600501.
Blaine KP, Steurer MP. Viscoelastic monitoring to guide the correction of perioperative coagulopathy and massive transfusion in patients with life-threatening hemorrhage. Anesthesiol Clin. 2019;37:51–66.
Haas T, Faraoni D. Viscoelastic testing in pediatric patients. Transfusion. 2020;60(suppl 6):S75–S85.
Parker RI. Coagulopathies in the PICU: DIC and liver disease. Crit Care Clin. 2013;29:319–333.
Oren H, Cingöz I, Duman M, Yilmaz S, Irken G. Disseminated intravascular coagulation in pediatric patients: clinical and laboratory features and prognostic factors influencing the survival. Pediatr Hematol Oncol. 2005;22:679–688.
Gando S, Iba T, Eguchi Y, ; Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006;34:625–631.
Voves C, Wuillemin WA, Zeerleder S. International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. Blood Coagul Fibrinolysis. 2006;17:445–451.
Khemani RG, Bart RD, Alonzo TA, Hatzakis G, Hallam D, Newth CJ. Disseminated intravascular coagulation score is associated with mortality for children with shock. Intensive Care Med. 2009;35:327–333.
Jhang WK, Ha E, Park SJ. Evaluation of disseminated intravascular coagulation scores in critically ill pediatric patients with septic shock. J Crit Care. 2018;47:104–108.
Iba T, Levy JH, Yamakawa K, Thachil J, Warkentin TE, Levi M; Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis. Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation. J Thromb Haemost. 2019;17:1265–1268.
Kander T, Larsson A, Taune V, Schött U, Tynngård N. Assessment of haemostasis in disseminated intravascular coagulation by use of point-of-care assays and routine coagulation tests, in critically ill patients; a prospective observational study. PLoS One. 2016;11:e0151202.
Müller MCA, Meijers JC, van Meenen DM, Thachil J, Juffermans NP. Thromboelastometry in critically ill patients with disseminated intravascular coagulation. Blood Coagul Fibrinolysis. 2019;30:181–187.
Csete ME. The eye of the beholder. Anesth Analg. 2018;126:23–24.
Durand P, Debray D, Mandel R, et al. Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center. J Pediatr. 2001;139:871–876.
Farmer DG, Venick RS, McDiarmid SV, et al. Fulminant hepatic failure in children: superior and durable outcomes with liver transplantation over 25 years at a single center. Ann Surg. 2009;250:484–493.
Wolber EM, Ganschow R, Burdelski M, Jelkmann W. Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood. Hepatology. 1999;29:1739–1742.
Lisman T, Porte RJ. Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood. 2010;116:878–885.
Hugenholtz GC, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT, Lisman T. An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome. Hepatology. 2013;58:752–761.
Agarwal B, Wright G, Gatt A, et al. Evaluation of coagulation abnormalities in acute liver failure. J Hepatol. 2012;57:780–786.
Leebeek FW, Rijken DC. The fibrinolytic status in liver diseases. Semin Thromb Hemost. 2015;41:474–480.
Bulut Y, Sapru A, Roach GD. Hemostatic balance in pediatric acute liver failure: epidemiology of bleeding and thrombosis, physiology, and current strategies. Front Pediatr. 2020;8:618119.
Munoz SJ, Stravitz RT, Gabriel DA. Coagulopathy of acute liver failure. Clin Liver Dis. 2009;13:95–107.
Lee A, Mendoza J, Brubaker AL, et al. Eliminating international normalized ratio threshold for transfusion in pediatric patients with acute liver failure. Clin Transplant. 2020;34:e13819.
Buliarca A, Horhat A, Mocan T, Craciun R, Procopet B, Sparchez Z. Viscoelastic tests in liver disease: where do we stand now? World J Gastroenterol. 2021;27:3290–3302.
de Boer MT, Christensen MC, Asmussen M, et al. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg. 2008;106:32–44.
Lisman T, Porte RJ. Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases. Res Pract Thromb Haemost. 2017;1:150–161.
Kloesel B, Kovatsis PG, Faraoni D, et al. Incidence and predictors of massive bleeding in children undergoing liver transplantation: a single-center retrospective analysis. Paediatr Anaesth. 2017;27:718–725.
Borst AJ, Sudan DL, Wang LA, Neuss MJ, Rothman JA, Ortel TL. Bleeding and thrombotic complications of pediatric liver transplant. Pediatr Blood Cancer. 2018;65:e26955.
Chan AK, Leaker M, Burrows FA, et al. Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass. Thromb Haemost. 1997;77:270–277.
Hickey E, Karamlou T, You J, Ungerleider RM. Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products. Ann Thorac Surg. 2006;81:S2367–S2372.
Cholette JM, Faraoni D, Goobie SM, Ferraris V, Hassan N. Patient blood management in pediatric cardiac surgery: a review. Anesth Analg. 2018;127:1002–1016.
Ali U, Goldenberg N, Foreman C, et al. Association between cyanosis, transfusion, and thrombotic complications in neonates and children undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2020;34:349–355.
Paparella D, Brister SJ, Buchanan MR. Coagulation disorders of cardiopulmonary bypass: a review. Intensive Care Med. 2004;30:1873–1881.
Jiritano F, Serraino GF, Ten Cate H, et al. Platelets and extra-corporeal membrane oxygenation in adult patients: a systematic review and meta-analysis. Intensive Care Med. 2020;46:1154–1169.
Balle CM, Jeppesen AN, Christensen S, Hvas AM. Platelet function during extracorporeal membrane oxygenation in adult patients. Front Cardiovasc Med. 2019;6:114.
Whitney G, Daves S, Hughes A, et al. Implementation of a transfusion algorithm to reduce blood product utilization in pediatric cardiac surgery. Paediatr Anaesth. 2013;23:639–646.
Manlhiot C, Menjak IB, Brandão LR, et al. Risk, clinical features, and outcomes of thrombosis associated with pediatric cardiac surgery. Circulation. 2011;124:1511–1519.
Emani S, Zurakowski D, Baird CW, Pigula FA, Trenor C III, Emani SM. Hypercoagulability panel testing predicts thrombosis in neonates undergoing cardiac surgery. Am J Hematol. 2014;89:151–155.
Palevsky PM, Zhang JH, O’Connor TZ, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7–20.
Seelhammer TG, Rowse P, Yalamuri S. Bivalirudin for maintenance anticoagulation during venovenous extracorporeal membrane oxygenation for COVID-19. J Cardiothorac Vasc Anesth. 2021;35:1149–1153.
Radulescu VC. Anticoagulation therapy in children. Semin Thromb Hemost. 2017;43:877–885.
Finkel KW, Podoll AS. Complications of continuous renal replacement therapy. Semin Dial. 2009;22:155–159.
Williams GD, Bratton SL, Ramamoorthy C. Factors associated with blood loss and blood product transfusions: a multivariate analysis in children after open-heart surgery. Anesth Analg. 1999;89:57–64.
Dieu A, Rosal Martins M, Eeckhoudt S, et al. Fresh frozen plasma versus crystalloid priming of cardiopulmonary bypass circuit in pediatric surgery: a randomized clinical trial. Anesthesiology. 2020;132:95–106.
Bønding Andreasen J, Hvas AM, Ravn HB. Marked changes in platelet count and function following pediatric congenital heart surgery. Paediatr Anaesth. 2014;24:386–392.
Petäjä J, Lundström U, Leijala M, Peltola K, Siimes MA. Bleeding and use of blood products after heart operations in infants. J Thorac Cardiovasc Surg. 1995;109:524–529.
Murphy LD, Benneyworth BD, Moser EAS, Hege KM, Valentine KM, Mastropietro CW. Analysis of patient characteristics and risk factors for thrombosis after surgery for congenital heart disease. Pediatr Crit Care Med. 2018;19:1146–1152.
Closson R, Mauer E, Stock A, et al. The use of hemostatic blood products in children following cardiopulmonary bypass and associated outcomes. Crit Care Explor. 2020;2:e0172.
Redlin M, Kukucka M, Boettcher W, et al. Blood transfusion determines postoperative morbidity in pediatric cardiac surgery applying a comprehensive blood-sparing approach. J Thorac Cardiovasc Surg. 2013;146:537–542.
Wolf MJ, Maher KO, Kanter KR, Kogon BE, Guzzetta NA, Mahle WT. Early postoperative bleeding is independently associated with increased surgical mortality in infants after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2014;148:631–6.e1.
Karanjkar A, Kapoor PM, Sharan S, et al. A prospective randomized clinical trial of efficacy of algorithm-based point of care guided hemostatic therapy in cyanotic congenital heart disease surgical patients. J Cardiac Crit Care TSS. 2019;3:816.
Faraoni D, Meier J, New HV, Van der Linden PJ, Hunt BJ. Patient blood management for neonates and children undergoing cardiac surgery: 2019 NATA guidelines. J Cardiothorac Vasc Anesth. 2019;33:3249–3263.
Fiser RT, Irby K, Ward RM, et al. RBC transfusion in pediatric patients supported with extracorporeal membrane oxygenation: is there an impact on tissue oxygenation? Pediatr Crit Care Med. 2014;15:806–813.
Bembea MM, Hoskote A, Guerguerian AM. Pediatric ECMO research: the case for collaboration. Front Pediatr. 2018;6:240.
Peta-Maree Ann A, Jennifer M; Grantome. Pediatric ECMO Antigoagulation Collabroative (PEACE) Consensus. 2015. Accessed May 14, 2022. https://grantome.com/grant/NIH/R13-HD104432-01 .
Cashen K, Dalton H, Reeder RW, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Platelet transfusion practice and related outcomes in pediatric extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2020;21:178–185.
Ozment CP, Scott BL, Bembea MM, Spinella PC; Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Extracorporeal Life Support Organization (ELSO). Anticoagulation and transfusion management during neonatal and pediatric extracorporeal membrane oxygenation: a survey of medical directors in the United States. Pediatr Crit Care Med. 2021;22:530–541.
Nellis ME, Saini A, Spinella PC, et al.; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the PlasmaTV Investigators and the P3T Investigators. Pediatric plasma and platelet transfusions on extracorporeal membrane oxygenation: a subgroup analysis of two large international point-prevalence studies and the role of local guidelines. Pediatr Crit Care Med. 2020;21:267–275.
Extracorporeal Life Support Organization. ELSO Guidelines for Cardiopulmonary Extracorporeal Life Support. 2017. Accessed February 15, 2022. http://www.elso.org/resources/guidelines.aspx .
Keene SD, Patel RM, Stansfield BK, Davis J, Josephson CD, Winkler AM. Blood product transfusion and mortality in neonatal extracorporeal membrane oxygenation. Transfusion. 2020;60:262–268.
Nellis ME, Dalton H, Karam O; PediECMO Investigators. Quantifiable bleeding in children supported by extracorporeal membrane oxygenation and outcome. Crit Care Med. 2019;47:e886–e892.
McManus ML, Kevy SV, Bower LK, Hickey PR. Coagulation factor deficiencies during initiation of extracorporeal membrane oxygenation. J Pediatr. 1995;126:900–904.
Arnold P, Jackson S, Wallis J, Smith J, Bolton D, Haynes S. Coagulation factor activity during neonatal extra-corporeal membrane oxygenation. Intensive Care Med. 2001;27:1395–1400.
McMichael ABV, Zimmerman KO, Kumar KR, Ozment CP. Evaluation of effect of scheduled fresh frozen plasma on ECMO circuit life: a randomized pilot trial. Transfusion. 2021;61:42–51.
Bembea MM, Annich G, Rycus P, Oldenburg G, Berkowitz I, Pronovost P. Variability in anticoagulation management of patients on extracorporeal membrane oxygenation: an international survey. Pediatr Crit Care Med. 2013;14:e77–e84.
Goobie SM, Haas T. Perioperative bleeding management in pediatric patients. Curr Opin Anaesthesiol. 2016;29:352–358.
Downey LA, Andrews J, Hedlin H, et al. Fibrinogen concentrate as an alternative to cryoprecipitate in a postcardiopulmonary transfusion algorithm in infants undergoing cardiac surgery: a prospective randomized controlled trial. Anesth Analg. 2020;130:740–751.
Ashikhmina E, Said S, Smith MM, et al. Prothrombin complex concentrates in pediatric cardiac surgery: the current state and the future. Ann Thorac Surg. 2017;104:1423–1431.

Auteurs

Stacey L Valentine (SL)

From the Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Jill M Cholette (JM)

Department of Pediatrics, Divisions of Critical Care Medicine and Cardiology, University of Rochester Golisano Children's Hospital, Rochester, New York.

Susan M Goobie (SM)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH