The Nuclear-to-Cytoplasmic Ratio: Coupling DNA Content to Cell Size, Cell Cycle, and Biosynthetic Capacity.
DNA-to-cytoplasmic ratio
biosynthetic activity
cell cycle
cell size
nuclear-to-cytoplasmic ratio
polyploidy
Journal
Annual review of genetics
ISSN: 1545-2948
Titre abrégé: Annu Rev Genet
Pays: United States
ID NLM: 0117605
Informations de publication
Date de publication:
30 11 2022
30 11 2022
Historique:
pubmed:
18
8
2022
medline:
3
12
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
Though cell size varies between different cells and across species, the nuclear-to-cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell maintains a relatively constant N/C ratio by coupling DNA content, nuclear size, and cell size. We explore how cells couple cell division and growth to DNA content. In some cases, cells use DNA as a molecular yardstick to control the availability of cell cycle regulators. In other cases, DNA sets a limit for biosynthetic capacity. Developmentally programmed variations in the N/C ratio for a given cell type suggest that a specific N/C ratio is required to respond to given physiological demands. Recent observations connecting decreased N/C ratios with cellular senescence indicate that maintaining the proper N/C ratio is essential for proper cellular functioning. Together, these findings suggest a causative, not simply correlative, role for the N/C ratio in regulating cell growth and cell cycle progression.
Identifiants
pubmed: 35977407
doi: 10.1146/annurev-genet-080320-030537
pmc: PMC10165727
mid: NIHMS1890010
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
165-185Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM113132
Pays : United States
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