During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes.

B7-H1 Antigen Humans Immunity Lymph Nodes Neoplasms / pathology Neutrophils
CP: Cancer CP: Immunology T lymphocytes adaptive immunity antigen-presenting cells cancer head and neck cancer immunosuppression lymph nodes metastasis neutrophils tumor

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
16 08 2022
Historique:
received: 30 07 2021
revised: 08 05 2022
accepted: 15 07 2022
entrez: 17 8 2022
pubmed: 18 8 2022
medline: 20 8 2022
Statut: ppublish

Résumé

Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation of anti-cancer adaptive immunity. Neutrophils form a substantial population of cells in LNs with poorly understood functions. Here, we demonstrate that, during head and neck cancer (HNC) progression, tumor-associated neutrophils transmigrate to LNs and shape anti-tumor responses in a stage-dependent manner. In metastasis-free stages (N0), neutrophils develop an antigen-presenting phenotype (HLA-DR

Identifiants

DOI: 10.1016/j.celrep.2022.111171 PMID: 35977505
pubmed: 35977505
pii: S2211-1247(22)00984-6
doi: 10.1016/j.celrep.2022.111171
pii:
doi:

Substances chimiques

B7-H1 Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111171

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Ekaterina Pylaeva (E)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany. Electronic address: ekaterina.pylaeva@uk-essen.de.

Georg Korschunow (G)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Ilona Spyra (I)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Sharareh Bordbari (S)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Elena Siakaeva (E)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Irem Ozel (I)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Maksim Domnich (M)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Anthony Squire (A)

Institute of Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Anja Hasenberg (A)

Institute of Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Kruthika Thangavelu (K)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Timon Hussain (T)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Moritz Goetz (M)

Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Karl S Lang (KS)

Institute of Immunology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Matthias Gunzer (M)

Institute of Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V, 44139 Dortmund, Germany.

Wiebke Hansen (W)

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Jan Buer (J)

Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Agnes Bankfalvi (A)

Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Stephan Lang (S)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany; German Cancer Consortium (DKTK), Partner Site Düsseldorf/Essen, 45147 Essen, Germany.

Jadwiga Jablonska (J)

Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany; German Cancer Consortium (DKTK), Partner Site Düsseldorf/Essen, 45147 Essen, Germany. Electronic address: jadwiga.jablonska@uk-essen.de.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › During early stages of cancer, neutrophils...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › During early stages of cancer, neutrophils...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › During early stages of cancer, neutrophils...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › During early stages of cancer, neutrophils...
questionsmedicales.fr › Tumeurs › During early stages of cancer, neutrophils...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › During early stages of cancer, neutrophils...