The spatiotemporal dynamics of microglia across the human lifespan.
RNA-seq
apoptosis
neurodevelopment
proliferation
single-cell RNA-seq
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
12 09 2022
12 09 2022
Historique:
received:
15
09
2021
revised:
22
04
2022
accepted:
26
07
2022
pubmed:
18
8
2022
medline:
16
9
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
Microglia, the brain's resident macrophages, shape neural development and are key neuroimmune hubs in the pathological signatures of neurodevelopmental disorders. Despite the importance of microglia, their development has not been carefully examined in the human brain, and most of our knowledge derives from rodents. We aimed to address this gap in knowledge by establishing an extensive collection of 97 post-mortem tissues in order to enable quantitative, sex-matched, detailed analysis of microglia across the human lifespan. We identify the dynamics of these cells in the human telencephalon, describing waves in microglial density across gestation, infancy, and childhood, controlled by a balance of proliferation and apoptosis, which track key neurodevelopmental milestones. These profound changes in microglia are also observed in bulk RNA-seq and single-cell RNA-seq datasets. This study provides a detailed insight into the spatiotemporal dynamics of microglia across the human lifespan and serves as a foundation for elucidating how microglia contribute to shaping neurodevelopment in humans.
Identifiants
pubmed: 35977545
pii: S1534-5807(22)00546-9
doi: 10.1016/j.devcel.2022.07.015
pmc: PMC9616795
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2127-2139.e6Subventions
Organisme : Medical Research Council
ID : MR/N004272/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P024572/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/006237/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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