The Chicken A and E Blood Systems Arise from Genetic Variation in and around the Regulators of Complement Activation Region.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
received:
20
10
2021
accepted:
07
07
2022
pubmed:
18
8
2022
medline:
24
9
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
The tightly linked A and E blood alloantigen systems are 2 of 13 blood systems identified in chickens. Reported herein are studies showing that the genes encoding A and E alloantigens map within or near to the chicken regulator of complement activation (RCA) gene cluster, a region syntenic with the human RCA. Genome-wide association studies, sequence analysis, and sequence-derived single-nucleotide polymorphism information for known A and/or E system alleles show that the most likely candidate gene for the A blood system is C4BPM gene (complement component 4 binding protein, membrane). Cosegregation of single-nucleotide polymorphism-defined C4BPM haplotypes and blood system A alleles defined by alloantisera provide a link between chicken blood system A and C4BPM. The best match for the E blood system is the avian equivalent of FCAMR (Fc fragment of IgA and IgM receptor). C4BPM is located within the chicken RCA on chicken microchromosome 26 and is separated from FCAMR by 89 kbp. The genetic variation observed at C4BPM and FCAMR could affect the chicken complement system and differentially guide immune responses to infectious diseases.
Identifiants
pubmed: 35977798
pii: jimmunol.2101010
doi: 10.4049/jimmunol.2101010
doi:
Substances chimiques
Complement C4
0
Immunoglobulin A
0
Immunoglobulin Fc Fragments
0
Isoantigens
0
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1128-1137Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.