Ramping activity in the striatum.
basal ganglia
computational model
interval discrimination
network dynamics
neural ramping
striatum
temporal estimation
Journal
Frontiers in computational neuroscience
ISSN: 1662-5188
Titre abrégé: Front Comput Neurosci
Pays: Switzerland
ID NLM: 101477956
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
03
2022
accepted:
05
07
2022
entrez:
18
8
2022
pubmed:
19
8
2022
medline:
19
8
2022
Statut:
epublish
Résumé
Control of the timing of behavior is thought to require the basal ganglia (BG) and BG pathologies impair performance in timing tasks. Temporal interval discrimination depends on the ramping activity of medium spiny neurons (MSN) in the main BG input structure, the striatum, but the underlying mechanisms driving this activity are unclear. Here, we combine an MSN dynamical network model with an action selection system applied to an interval discrimination task. We find that when network parameters are appropriate for the striatum so that slowly fluctuating marginally stable dynamics are intrinsically generated, up and down ramping populations naturally emerge which enable significantly above chance task performance. We show that emergent population activity is in very good agreement with empirical studies and discuss how MSN network dysfunction in disease may alter temporal perception.
Identifiants
pubmed: 35978564
doi: 10.3389/fncom.2022.902741
pmc: PMC9376361
doi:
Types de publication
Journal Article
Langues
eng
Pagination
902741Informations de copyright
Copyright © 2022 Ponzi and Wickens.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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